Adipogen/(R)-3-Hydroxybutyric acid/AG-CR1-3616-M025/25 mg
商品编号：
AG-CR1-3616-M025
品牌：
Adipogen Inc
市场价：
¥700.00
美元价：
420.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (R)-β-Hydroxybutyricacid;D-(-)-3-Hydroxybutyricacid;D-(-)-BHB |
| ProductType | Chemical |
| Properties | |
| Formula | C4H8O3 |
| MW | 104.1 |
| MerckIndex | 14:4816 |
| CAS | 625-72-9 |
| PurityChemicals | ≥98%(TLC) |
| Appearance | Whitesolid. |
| Solubility | Solubleinwater,100%ethanolormethanol. |
| Identity | Determinedby1H-NMR. |
| OtherProductData | OpticalRotation:[α]20/Dc=6inH2O:-25°±1.0° |
| InChiKey | WHBMMWSBFZVSSR-GSVOUGTGSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Keymetaboliteoftheketolyticpathwaygeneratingacetyl-CoA.
- StereoselectiveproductofD-3-hydroxybutyratedehydreogenase.Clinicallyandphysiologicallysignificantstereoisomer.
- EnergycarrierfromADIpocytestoperipheraltissuesduringfastingorexercise.
- Endogenousinhibitorofhistonedeacetylases(HDACs)1,3and4.
- Ligandoffreefattyacidreceptor3(FFAR3;GPR41)andhydroxycarboxylicacidreceptor2(HCAR2;GPR109B).
- NLRP3inflammasomeinhibitor.PreventsK+-effluxandreducesASColigomerizationandspeckformation.
ProductReferences
- Effectsofbeta-hydroxybutyricacidoninsulinbindingtoitsreceptorandonautophosphorylationofthereceptor:H.Ohtusaka,etal.;Endocrinol.Jpn.37,915(1990)
- Thedirectmeasurementof3-beta-hydroxybutyrateenhancesthemanagementofdiabeticketoacidosisinchildrenandreducestimeandcostsoftreatment:M.Vanelli,etal.;Diab.Nutr.Metab.16,312(2003)
- Detectionofcerebral{beta}-hydroxybutyrate,acetoacetate,andlactateonprotonMRspectroscopyinchildrenwithdiabeticketoacidosis:S.L.Wootton-Gorges,etal.;AJNR26,1286(2005)
- β-HydroxybutyrateactivatestheNF-κBsignalingpathwaytopromotetheexpressionofpro-inflammatoryfactorsincalfhepatocytes:X.Shi,etal.;Cell.Physiol.Biochem.33,920(2014)
- β-hydroxybutyrate:Muchmorethanametabolite:J.C.Newman&E.Verdin;Diab.Res.Clin.Pract.106,173(2014)(Review)
- BHBAsuppressesLPS-inducedinflammationinBV-2cellsbyinhibitingNF-κBactivation:S.P.Fu,etal.;Med.Inflamm.2014,ID983401(2014)
- Anti-inflammatoryeffectsofBHBAinbothinvivoandinvitroParkinson"sdiseasemodelsaremediatedbyGPR109A-dependentmechanisms:S.P.Fu,etal.;J.Neuroinflamm.12,ID9(2015)
- Theketonemetaboliteβ-hydroxybutyrateblocksNLRP3inflammasome-mediatedinflammatorydisease:Y.H.Youm,etal.;Nat.Med.21,263(2015)
- Tamingtheinflammasome:M.Levy,etal.;Nat.Med.21,213(2015)
- Inflammasomeinhibition:puttingoutthefire:M.G.Netea&L.A.Joosten;CellMetab.21,513(2015)
- Inflammasome:starvinginflammation:E.Kugleberg;Nat.Rev.Immunol.15,199(2015)(Review)
- TheNlrp3inflammasomeadmitsdefeat:C.J.Gross&O.Gross;TrendsImmunol.36,323(2015)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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