Adipogen/(-)-Epigallocatechin gallate/AG-CN2-0063-M100/100 mg
商品编号：
AG-CN2-0063-M100
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Epigallocatechin-3-gallate;EGCG;CCRIS3729;Teavigo;NVP-XAA723 |
| ProductType | Chemical |
| Properties | |
| Formula | C22H18O11 |
| MW | 458.4 |
| MerckIndex | 14:3526 |
| CAS | 989-51-5 |
| RTECS | KB5200000 |
| Source/HostChemicals | Isolatedfromgreentea. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Off-whitetowhitepowder. |
| Solubility | SolubleinDMSO,ethanol,dimethylformamideandwater. |
| Identity | Determinedby1H-NMRandMS. |
| InChiKey | WMBWREPUVVBILR-WIYYLYMNSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Keepunderinertgas. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Afterreconstitution,preparealiquotsandstoreat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentanticancercompound.
- Anti-angiogenic.VEGF,VE-cadherinphosphorylation,matrixmetalloproteinaseandurokinase-plasminogenactivator(uPA)inhibitor.
- Anti-inflammatory.NF-κBinhibitor.Modulateschronicinflammatorydiseases,suchastype2diabetes,rheumatoidarthritis,inflammatoryboweldisease.
- COX-2andinducIBLenitricoxidesynthase(iNOS;NOSII)inhibitor.
- Potentantioxidant.ProtectscellsfromlipidperoxidationandDNAdamageinducedbyreactivefreerADIcals.
- Regulatescancercellgrowth,proliferation,transformation,survival,angiogenesis,apoptosis,invasionandmetastasis.
- Chemopreventive.Apoptosisinducer.Promotescellcyclearrest.
- ModulatessignaltransductionpathwaysincludingJAK/STAT,MAPK,PI3K/AKT,WntandNotch.
- EGFRandHER-2receptorsignalinginhibitor.
- MAPKsandactivatorprotein-1inhibitor.
- PotentDYRK1Ainhibitor(IC50=330nM).
- mTORsuppressor.
- IGF-Isignalinginhibitor.
- Proteasomeinhibitor.
- TelomeraseandDNAmethyltransferaseinhibitor.
- SelectiveandnoncompetitiveHATinhibitor.
- TopoisomeraseIandIIinhibitor.
- Hedgehogsignaling(Hh)modulator.PTCHandGli1inhibitor.
- Wntsignalinginhibitor.
- Neuroprotective.ActivatesHO-1bytheARE/Nrf2pathway,protectingneuronsagainstoxidativedamage.
- STAT-1inhibitor.
- Showspreventivecardiovascularandmetabolic(obesity,insulinresistance,hypertensionandhypercholesterolemia)effects.
- Inhibitsextracellularsignal-relatedkinases(ERK),activatesAMP-activatedproteinkinase(AMPK),modulatesadipocyteMarkerproteinsanddown-regulateslipogenicenzymesaswellasotherpotentialtargets.
- Fattyacidsynthase(FAS)inhibitor.
- Autophagystimulator.
ProductReferences
- Molecularmechanismsunderlyingchemopreventiveactivitiesofanti-inflammatoryphytochemicals:down-regulationofCOX-2andiNOSthroughsuppressionofNF-kappaBactivation:Y.J.Surh,etal.;Mutat.Res.480-481,243(2001)(Review)
- Thespecificitiesofproteinkinaseinhibitors:anupdate:J.Bain,etal.;Biochem.J.371,199(2003)
- Targetingmultiplesignalingpathwaysbygreenteapolyphenol(-)-epigallocatechin-3-gallate:N.Khan,etal.;CancerRes.66,2500(2006)(Review)
- Inhibitionoffattyacidsynthasebypolyphenols:W.X.Tian;Curr.Med.Chem.13,967(2006)(Review)
- Greenteapolyphenolsasanaturaltumourcellproteasomeinhibitor:Q.P.Dou,etal.;Inflammopharmacology16,208(2008)(Review)
- Chemopreventionwithphytochemicalstargetinginduciblenitricoxidesynthase:A.Murakami;ForumNutr.61,193(2009)(Review)
- MolecularbasisforcancerchemopreventionbygreenteapolyphenolEGCG:H.Tachibana;ForumNutr.61,156(2009)(Review)
- Apoptosisbydietaryagentsforpreventionandtreatmentofprostatecancer:N.Khan,etal.;Endocr.Relat.Cancer17,R39(2010)(Review)
- Targetingpolyaminesandbiogenicaminesbygreenteaepigallocatechin-3-gallate:E.Melgarejo,etal.;AminoAcids38,519(2010)(Review)
- Greenteapolyphenolepigallocatechin-3-gallate:inflammationandarthritis:R.Singh,etal.;LifeSci.86,907(2010)(Review)
- Regulationofsurvival,proliferation,invasion,angiogenesis,andmetastasisoftumorcellsthroughmodulationofinflammatorypathwaysbynutraceuticals:S.C.Gupta,etal.;CancerMetastasisRev.29,405(2010)(Review)
- UpdatesofmTORinhibitors:H.Zhou,etal.;AnticancerAgentsMed.Chem.10,571(2010)(Review)
- TheroleofnutraceuticalsintheregulationofWntandHedgehogsignalingincancer:F.H.Sarkar,etal.;CancerMetastasisRev.29,383(2010)(Review)
- UseofSTAT1inhibitorsinthetreatmentofbrainI/Rinjuryandneurodegenerativediseases:F.H.Ebner,etal.;Cent.Nerv.Syst.AgentsMed.Chem.11,2(2011)(Review)
- Weightcontrolandpreventionofmetabolicsyndromebygreentea:S.Sae-tan,etal.;Pharmacol.Res.64,146(2011)(Review)
- Targetingcellsignalingandapoptoticpathwaysbydietaryagents:roleinthepreventionandtreatmentofcancer:M.K.Shanmugam,etal.;Nutr.Cancer63,161(2011)(Review)
- Implicationsofcancerstemcelltheoryforcancerchemopreventionbynaturaldietarycompounds:Y.Li,etal.;J.Nutr.Biochem.22,799(2011)(Review)
- ModulationofNrf2/AREpathwaybyfoodpolyphenols:anutritionalneuroprotectivestrategyforcognitiveandneurodegenerativedisorders:G.Scapagnini,etal.;Mol.Neurobiol.44,192(2011)(Review)
- NutritionalapproachestomodulateoxidativestressinAlzheimer"sdisease:C.B.Pocernich,etal.;Curr.AlzheimerRes.8,452(2011)(Review)
- Possibleinvolvementofprogrammedcelldeathpathwaysintheneuroprotectiveactionofpolyphenols:S.Bastianetto,etal.;Curr.AlzheimerRes.8,445(2011)(Review)
- Greenteacatechin,epigallocatechin-3-gallate(EGCG):mechanisms,perspectivesandclinicalapplications:B.N.Singh,etal.;Biochem.Pharmacol.82,1807(2011)(Review)
- Epigeneticdiet:impactontheepigenomeandcancer:T.M. Hardy&T.O.Tollefsbol;Epigenomics3,503(2011)(Review)
- GreenteaEGCG,Tcells,andTcell-mediatedautoimmunediseases:D.Wu,etal.;Mol.AspectsMed33,107(2012)(Review)
- Epigallocatechin-3-gallate,aDYRK1Ainhibitor,rescuescognitivedeficitsinDownsyndromemousemodelsandinhumans:R.DelaTorre,etal.;Mol.Nutr.FoodRes.58,278(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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