Adipogen/(+)-Aphidicolin/BVT-0307-M025/25 mg
商品编号：
BVT-0307-M025
品牌：
Adipogen Inc
市场价：
¥15800.00
美元价：
9480.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NSC234714;BRN4689958;ICI69653 |
| ProductType | Chemical |
| Properties | |
| Formula | C20H34O4 |
| MW | 338.5 |
| MerckIndex | 14:727 |
| CAS | 38966-21-1 |
| RTECS | PB9185000 |
| Source/HostChemicals | IsolatedfromPhomasp.BS7210. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO(50mg/ml),methanol(10mg/ml)or100%ethanol;insolubleinwater. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | NOFOAYPPHIUXJR-APNQCZIXSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat+4°C. Afterreconstitutionprotectfromlightat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Phytotoxin.
- Antibiotic.
- Antiviralandantineoplasticagent.
- Antileishmanialagent.
- ReversIBLeinhibitorofeukaryoticnuclearDNAreplication.
- Usefulforcellsynchronization.
- BlocksthecellcycleatG1/Sphase.
- ProlongsthehalflifeofDNAmethyltransferase.DNAmethylation/demethylationmodulator.
- SpecificDNApolymeraseαandδinhibitorineukaryoticcellsandinsomevirusesofanimalorigin.
- Actssynergisticallywithvincristineanddoxorubicin.
- Apoptosisinhibitor/inducer.
ProductReferences
- X-Raycrystallographicdeterminationofthestructureoftheantibioticaphidicolin:atetracyclicditerpenoidcontaininganewringsystem:K.M.Brundret,etal.;J.C.S.Chem.Commun.1027(1972)
- TheproductionofaphidicolinbyNigrosporasphaerica:A.N.StarrattandS.RLoschiavo;Can.J.Microbiol.20,416(1974)
- AphidicolinpreventsmitoticcelldivisionbyinterferingwiththeactivityofDNApolymerase-alpha:S.Ikegami,etal.;Nature275,458(1978)
- NewviewsofthebiochemistryofeucaryoticDNAreplicationrevealedbyaphidicolin,anunusualinhibitorofDNApolymerasealpha:J.A.Huberman;Cell23,647(1981)
- Aphidicolin:aspecificinhibitorofnuclearDNAreplicationineukaryotes:S.Spadari,etal.;TIBS7,29(1982)
- Aphidicolinpotentiatesapoptosisinducedbyarabinosylnucleosidesinhumanmyeloidleukemiacelllines:K.Kuwakado,etal.;Biochem.Pharmacol.46,1909(1993)
- Dissociationofnuclearandcytoplasmiccellcycleprogressionbydrugsemployedincellsynchronization:L.Urbani,etal.;Exp.Cell.Res.219,159(1995)
- Drug-inducedapoptosisisnotnecessarilydependentonmacromolecularsynthesisorproliferationinthep53-negativehumanprostatecancercelllinePC-3:M.M.Borner,etal.;CancerRes.55,2122(1995)
- TrkAneurogenicreceptorregulatesdifferentiationofneuroblastomacells:W.Poluha,etal.;Oncogene10,185(1995)
- EffectofaphidicolinonDNAmethyltransferaseinthenucleus:I.Suetake,etal.;CellStruct.Funct.23,137(1998)
- Cytotoxicityofaphidicolinanditsderivativesagainstneuroblastomacellsinvitro:synergismwithdoxorubicinandvincristine:M.Michaelis,etal.;AnticancerDrugs11,479(2000)
- Antileishmanialactivitiesofaphidicolinanditssemisyntheticderivatives:O.Kayser,etal.;Antimicrob.AgentsChemother.45,288(2001)
- AphidicolinandbleomycininducedchromosomedamageasbioMarkerofmutagensensitivity:atwinstudy:B.Tedeschi,etal.;Mutat.Res.546,55(2004)
- HumanpapillomavirusepisomestabilityisreducedbyaphidicolinandcontrolledbyDNAdamageresponsepathways:T.G.Edwards,etal.;J.Virol.87,3979(2013)
- Aphidicolin-inducednuclearelongationintobaccoBY-2cells:H.Yashura,etal.;PlantCellPhysiol.55,913(2014)
- ActiveandpassivedemethylationofmaleandfemalepronuclearDNAinthemammalianzygote:F.Guo,etal.;CellStemCell15,447(2014)
- StructuralbasisforinhibitionofDNAreplicationbyaphidicolin:A.G.Baranovskiy,etal.;Nucl.AcidsRes.42,14013(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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