Adipogen/α-Galactosylceramide/AG-CN2-0013-M001/1 mg
商品编号：
AG-CN2-0013-M001
品牌：
Adipogen Inc
市场价：
¥5200.00
美元价：
3120.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | α-Gal-Cer;KRN7000 |
| ProductType | Chemical |
| Properties | |
| Formula | C50H99NO9 |
| MW | 858.3 |
| CAS | 158021-47-7 |
| PurityChemicals | ≥96%(NMR) |
| Appearance | Off-whitesolid. |
| Solubility | Solubleinpyridine.SolubilizationinTween20orPBSforcellcultureuseseeonlineprotocol. |
| Identity | Identitydeterminedby1H-NMR. |
| Declaration | ManufacturedbyADIpogen.NotsoldinJapan. |
| InChiKey | LSUQVAFARUJTHS-ABBGRRHVSA-N |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Aliquotintoglassvials. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| Protocols |  DownloadPDF |
| MSDS | DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Synthetic.Originallyisolatedfromthemarinesponge Angelasmauritianus [1].
- Immunostimulant[1,2,3].
- PotentstimulatorofnaturalkillerT(NKT)cells[4,5].
- Specificligandofthelipid-bindingMHCclassI-likeproteinCD1dinhumanandmouseNKTcells[5].
- ProtectsagainstLPS-inducedshock[7].
- Potentantitumorcompound [2,6,8].
ProductReferences
- Synthesisofalpha-,beta-monoglycosylceramidesandfourdiastereomersofanalpha-galactosylceramide:M.Morita,etal.;Bioorg.Med.Chem.Lett.5,699(1995)
- Immunostimulatoryandantitumoractivitiesofmonoglycosylceramideshavingvarioussugarmoieties:K.Motoki,etal.;Biol.Pharm.Bull.18,1487(1995)
- Immunostimulatoryactivitiesofmonoglycosylatedalpha-D-pyranosylceramides:A.Uchimura,etal.;Bioorg.Med.Chem.5,2245(1997)
- ActivationofnaturalkillerTcellsbyalpha-galactosylceramiderapidlyinducesthefullmaturationofdendriticcellsinvivoandtherebyactsasanadjuvantforcombinedCD4andCD8TcellimmunitytoacoadmiNISTeredprotein:FujiiS,etal.;J.Exp.Med.198,267(2003)
- ModulationofCD1d-restrictedNKTcellresponsesbyusingN-acylvariantsofalpha-galactosylceramides:K.O.Yu,etal.;PNAS102,3383(2005)
- AphaseIstudyofalpha-galactosylceramide(KRN7000)-pulseddendriticcellsinpatientswithadvancedandrecurrentnon-smallcelllungcancer:A.Ishikawa,etal.;Clin.CancerRes.11,1910(2005)
- Pivotaladvance:alpha-galactosylceramideinducesprotectionagainstlipopolysaccharide-inducedshock:G.Sireci,etal.;J.Leukoc.Biol.81,607(2007)
- α-Galactosylceramideactivatesantitumorimmunityagainstlivertumor:T.Tatsumi,etal.;Hepatol.Res.41,160(2011)
- DeletionofCD1dinadipocytesaggravatesadiposetissueinflammationandinsulinresistanceinobesity:J.Y.Huh,etal.;Diabetes66,835(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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