脂肪原/MDM2/p53（人）泛素化试剂盒/AG-44T-0118-KI01/1试剂盒
商品编号：
AG-44T-0118-KI01
品牌：
Adipogen Inc
市场价：
¥17620.00
美元价：
10572.00
产品分类：
其它检测试剂盒
公司分类：
Other_kits
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | MDM2[HDM2]UbiquitinLigaseKit-p53Substrate |
| ProductType | Kit |
| Properties | |
| ApplicationSet | CompoundScreening |
| Crossreactivity | Human |
| KitContains | 30μlof10XE1Enzyme 30μlof10XE2Enzyme(UBE2D3) 30μlof10XGST-MDM2 30μlof10XHis-p53ControlSubstrate 30μlof10XUbiquitinSolution 50μlof10XReactionBuffer 30μlof10XMg-ATPSolution 100μlofα-p53Primaryantibody 1mlof5XLoADIngBuffer NOTE:Kitcontainsreagentssufficientfor10x30μlreactionsand5WesternBlots(mini-gelformat). |
| OtherProductData | Use:Thiskitisdesignedforinvitroubiquitinationofp53byMdm2.TheubiquitinatedproteincanbedetectedbyWesternblotusingthesuppliedanti-p53monoclonalantibody.ThiskitcanbeusedasapositivecontrolinstudiesthatmonitortheactivitiesofotherknownorputativeE3ligaseenzymesthatubiquitinatep53.Ubiquitinatedp53substratecanalsobeusedtostudyE4ligaseactivitiesofenzymessuchasUBE4B,ortheactivityofdeubiquitinatingenzymessuchasUSP7. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-80°C. |
| Documents | |
| Manual |  DownloadPDF |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
MDM2isakeyregulatorofp53tumorsuppressorproteinactivityandstability.MDM2bindstoandinhibitsthetransactivationdomainofp53.Inaddition,MDM2controlsp53stabilitybyfunctioningasitsE3ligaseinubiquitinationandbyshuttlingp53fromthenucleustothecytoplasmforsubsequentdegradation.Theimportanceofthep53/MDM2relationshipisunderscoredbytheexistenceofanautoregulatoryfeedbackloopwherebyactivatedp53transcriptionallyupregulatestheexpressionofitsowninhibitor,MDM2.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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