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脂肪原/抗寨卡病毒包膜蛋白（EIII结构域），单克隆抗体（rec.）（中和）（ZKA64）（无防腐剂）/AG-27B-6004PF-
脂肪原/抗寨卡病毒包膜蛋白（EIII结构域），单克隆抗体（rec.）（中和）（ZKA64）（无防腐剂）/AG-27B-6004PF-
商品编号：
AG-27B-6004PF-C100
品牌：
Adipogen Inc
市场价：
¥7600.00
美元价：
4560.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ZIKVEProtein |
| ProductType | RecombinantAntibody |
| Properties | |
| Clone | ZKA64 |
| Isotype | HumanIgG1κ |
| Immunogen/Antigen | ZikaVirus |
| Label/Conjugates | PreservativeFree |
| Application | FunctionalApplication(Neutralizing):NeutralizesZikaVirus(ZIKV)withanIC50of~93ng/ml.AlsoenhancesZIKVinfectioninnon-permissiveK562cellsatabroadrangeofconcentrations(notabove1µg/ml). Optimalconditionsshouldbedeterminedindividually. |
| Crossreactivity | Virus |
| Specificity | RecognizesandbindsspecificallytotheEDIIIdomainoftheZikaVirusenvelopeprotein(ZIKVE).Itdoesnotcross-reactwithDenguevirusenvelopeprotein(DENVE). |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinA-affinitypurified. |
| EndotoxinContent | <0.001eu mu;g=""> |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBS. |
| OtherProductData | Source:EBV-immortalizedmemoryBcellsderivedfromZIKV-infected,DENV-naïvehumandonors. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Stableforatleast3monthsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
ThemainrouteofZikaVirus(ZIKV)infectionisthroughbitesbyAedesmosquitos,butthevirusmayalsobesexuallyandverticallytransmitted.AlthoughmostoftheZIKVinfectionsareasymptomaticorcauseonlymildsymptoms,thereisevidencethatZIKVinfectioncanleadtoneurologicalcomplications,suchasGuillain-Barrésyndromeinadultsandcongenitalbirthdefects,includingmicrocephalyinthedevelopingfetus,likelythroughitsabilitytoinfecthumanneuralProgenitorcells.Whereasflavivirusenvelope(E)proteinsmediatefusionandarethemaintargetofneutralizingantibodies,thenon-structuralprotein1(NS1)issecretedbyinfectedcellsandisinvolvedinimmuneevasionandpathogenesis.TheEproteincontainsthreedomains:EDIinvolvedintheconformationalchangesrequiredforviralentry;EDIIcontainingthefusionloop;andEDIIIwhichmaybeinvolvedinbindingtocellularreceptors.ThebestspecificneutralizingantibodiestoZIKVaredirectedagainstthedomainEDIIIofZIKV.
ProductReferences
- Specificity,cross-reactivity,andfunctionofantibodieselicitedbyZikavirusinfection:K.Stettler,etal.;Science353,823(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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