脂肪原/抗ZBP1，单克隆抗体（Zippy-1）/AG-20B-0010-C100/100µg
商品编号：
AG-20B-0010-C100
品牌：
Adipogen Inc
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Z-DNA-bindingProtein1;TumorStromaandActivatedMacrophageProteinDLM-1;DNA-dependentActivatorofIFN-regulatoryFactors;DAI |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | Zippy-1 |
| Isotype | MouseIgG2a |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | RecombinantmouseZBP1(aa1-411). |
| Application | Immunocytochemistry:(1:500)(seereference1) Immunoprecipitation:(1:200) WesternBlot:(1:1’000) |
| Crossreactivity | Human Mouse |
| Specificity | RecognizeshumanandmouseZBP1. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
ZBP1isaninterferoninducIBLeproteinthatbindstocytoplasmicDNAandplaysaroleinhostdefenseagainsttumorsandpathogens.ZBP1ishighlyexpressedinlymphatictissuesincludinglymphnode,leukocytes,tonsil,bonemarrowandspleen.ZBP1isaninnateimmunesensorofInfluenzaAvirus(IAV).ZBP1regulatesNLRP3(nucleotideandoligomerizationdomain,leucine-richrepeat-containingproteinfamily,pyrindomaincontaining3)inflammasomeactivationaswellasinductionofdifferenttypesofcelldeath(apoptosis,necroptosisandpyroptosis)duringIAVinfection.
ProductReferences
- ZBP1/DAIisaninnatesensorofinfluenzavirustriggeringtheNLRP3inflammasomeandprogrammedcelldeathpathways:T.Kuriakose,etal.;Sci.Immunol.1,aag2045(2016)
- DAIsensesInfluenzaAvirusgenomicRNAandactivatesRIPK3-dependentcelldeath:R.J.Thapa,etal.;CellHost&Microbe20,674(2016)
- RIPK1counteractsZBP1-mediatednecroptosistoinhibitinflammation:J.Lin,etal.;Nature540,124(2016)
- RIPK1inhibitsZBP1-drivennecroptosisduringdevelopment:K.Newton,etal.;Nature540,129(2016)
- IRF1IsaTranscriptionalRegulatorofZBP1PromotingNLRP3InflammasomeActivationandCellDeathduringInfluenzaVirusInfection:T.Kuriakose,etal.;J.Immunol.aheadofprint(2018)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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