Adipogen/anti-ZAP70, mAb (49B4)/YIF-LF-MA0197/100 µl
商品编号：
YIF-LF-MA0197
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SRK;ZAP70;EC=2.7.10.2;Syk-relatedTyrosineKinase;Tyrosine-ProteinKinaseZAP-70;70kDazeta-ChainAssociatedProtein |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 49B4 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanABD-ZAP70proteinpurifiedfromE.coli. |
| Application | ELISA WesternBlot(1:10,000) Immunoprecipitation(2μl) |
| Crossreactivity | Human |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
ζ-chainassociatedproteinkinase,ZAP70,isa70kDamemberoftheSykfamilykinasepredominantlyinvolvedinTcellreceptor(TCR)signaling.ItisstructurallyhomologoustoSyk,aPTKthatisinvolvedinproximalBCRsignaling.ZAP-70isakeysignalingmoleculeinTcellactivationandalsoplaysaroleinapoptosisandcellmigration.SYKfamilytyrosinekinasescontainaC-terminalkinasedomainandtandemN-terminalSH2domainsthatbindphosphorylatedITAMs(immunoreceptortyrosine-basedactivationmotif).LinkerregionthatcontainsmultipletyrosinesseparatestheSH2domainsfromthekinasedomain.PhosphorylatedtyrosinesactasdockingsitesforphospholipaseCγ1(PLCγ1).ZAP-70andSykarefunctionallyhomologousinantigenreceptorsignaling.ExpressionofZAP-70inSyk−BcellsreconstitutesSCRfunction.ReconstitutionrequiresthepresenceoffunctionalSrchomology2(SH2)andcatalyticdomainsofZAP-70.ExpressionofZAP-70isanimportantnegativeprognosticfactorinchroniclymphocyticleukemia(CLL)withmorerapiddiseaseprogressionandshortersurvival.PlaysaroleinT-celldevelopmentandlymphocyteactivation.EssentialforTCR-mediatedIL-2production.Isoform1inducesTCR-mediatedsignaltransduction,isoform2doesnot.
ProductReferences
1)GobessiS.etal.,(2007)Blood.109:2032-2039.(General)
2)OrchardJ.A.etal.,(2004)Lancet.363:105-111.(General)
3)KongG.H.etal.,(1995)Immunity.2:485-492.(General)
2)OrchardJ.A.etal.,(2004)Lancet.363:105-111.(General)
3)KongG.H.etal.,(1995)Immunity.2:485-492.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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