Adipogen/anti-Vitronectin, mAb (10E12)/YIF-LF-MA0205/100 µl
商品编号：
YIF-LF-MA0205
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | VTN |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 10E12 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | Proteinpurifiedfromhumanplasma. |
| Application | ELISA WesternBlot(1:5,000) IHC-P |
| Crossreactivity | Human |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Vitronectinisan75kDaglycoproteinconsistingof459aminoacidresidues.Itisabundantinbloodplasmaandtheextracellularmatrix.Vitronectincontainsthreeglycosylationsitesthatcontributeapproximately30%ofitsmolecularmass.Itcirculatesasasingle-chain(75kDa)andtwo-chain(10and65kDa)formsunderreducingconditions.Undernon-reducingconditions,theN-terminal65kDaandC-terminal10kDafragmentsarelinkedbyasingledisulfidebond.Vitronectinhasbeenimplicatedasaregulatorofmanydiversephysiologicalprocessesincludingcoagulation,fibrinolysis,pericellularproteolysis,complementdependentimmuneresponse,cellattachmentandspreADIng.Celladhesionandmigrationaredirectlyinvolvedincancermetastasisandtumormalignancy.TheSomatomedinBdomainofVitronectinbindstoPlasminogenactivatorinhibitor-1(PAI-1),andstabilizesit.Thusvitronectinservestoregulateproteolysisinitiatedbyplasminogenactivation.AdditionallyvitronectinisacomponentofplateletsandisthusinvolvedinhemostasisviaheparinbindingwhichneutralizingantithrombinIIIinhibitionofthrombinandfactorXa.VitronectincontainsanRGD(45-47)sequencewhichisabindingsiteformembraneboundintegrins,whichservetoanchorcellstotheextracellularmatrix.Vitronectinisacelladhesionandspreadingfactorfoundinserumandtissues.Vitronectininteractwithglycosaminoglycansandproteoglycans.Isrecognizedbycertainmembersoftheintegrinfamilyandservesasacell-to-substrateadhesionmolecule.Inhibitorofthemembrane-damagingeffectoftheterminalcytolyticcomplementpathway.Somatomedin-Bisagrowthhormone-dependentserumfactorwithprotease-inhibitingactivity.
ProductReferences
1.EkmekçiOBandEkmekçiH.,(2006)ClinChimActa.368(1-2):77-83.(General)
2.LijnenHR.(2005)JThrombHaemost.3(1):35-45.(General)
2.LijnenHR.(2005)JThrombHaemost.3(1):35-45.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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