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Adipogen/anti-VEGFR-1 (human), mAb (EWF)/AG-20T-0107-C100/100 µg
Adipogen/anti-VEGFR-1 (human), mAb (EWF)/AG-20T-0107-C100/100 µg
商品编号：
AG-20T-0107-C100
品牌：
Adipogen Inc
市场价：
¥9200.00
美元价：
5520.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | VascularEndothelialGrowthFactorReceptor-1;FLT-1;Fms-likeTyrosineKinase1 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | EWF |
| Isotype | MouseIgG1 |
| Immunogen/Antigen | RecombinanthumansolubleextracellularVEGFR-1. |
| Application | Immunoprecipitation:(1-5μg/ml) ELISA:(1-10μg/ml) WesternBlot:(1-10μg/ml) Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Human |
| Specificity | TheantibodywilldetectnativehumanVEGFR-1/Flt-1inELISAexperiments,WBandIP. |
| Purity | ProteinGpurified. |
| PurityDetail | ProteinGpurified. |
| Formulation | Lyophilized. |
| Reconstitution | Centrifugevialpriortoopening.Reconstitutewithsterilewatertoaconcentrationof0.1-1.0mg/ml. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Recombinanthumansolublevascularendothelialgrowthfactorreceptor-1(sVEGFR-1)isthenaturallyoccurringformandisaglycosylatedmonomericprotein.TheBIOLOGicalfunctionofsVEGFR-1seemstobeanendogenousregulatorofangiogenesis,bindingVEGFwiththesameaffinityasthefull-lengthreceptor.VEGFR-1isatyrosine-proteinkinasethatactsasacell-surfacereceptorforVEGFA,VEGFBandPGF,andplaysanessentialroleinthedevelopmentofembryonicvasculature,theregulationofangiogenesis,cellsurvival,cellmigration,macrophagefunction,chemotaxisandcancercellinvasion.Itmayplayanessentialroleasanegativeregulatorofembryonicangiogenesisbyinhibitingexcessiveproliferationofendothelialcells.Itcanpromoteendothelialcellproliferation,survivalandangiogenesisinadulthood.Itsfunctioninpromotingcellproliferationseemstobecell-typespecific.PromotesPGF-mediatedproliferationofendothelialcells,proliferationofsometypesofcancercells,butdoesnotpromoteproliferationofnormalfibroblasts(invitro).IthasaveryhighaffinityforVEGFAandrelativelylowproteinkinaseactivity.ItmayfunctionasanegativeregulatorofVEGFAsignalingbylimitingtheamountoffreeVEGFAandpreventingitsbindingtoKDR.ModulatesKDRsignalingbyformingheterodimerswithKDR.Ligandbindingleadstotheactivationofseveralsignalingcascades.ActivationofphospholipaseC-γ(PLCG)leadstotheproductionofthecellularsignalingmoleculesdiacylglycerolandinositol1,4,5-trisphosphateandtheactivationofproteinkinaseC.MediatesphosphorylationofPIK3R1,theregulatorysubunitofphosphatidylinositol3-kinase,leADIngtoactivationofphosphatidylinositolkinaseandthedownstreamsignalingpathway.MediatesactivationofMAPK1/ERK2,MAPK3/ERK1andtheMAPkinasesignalingpathway,aswellasoftheAKT1signalingpathway.PhosphorylatesSRCandYES1andmayalsophosphorylateCBL.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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