Adipogen/anti-VASP, pAb (IG-731)/AG-25T-0109-C025/25 µg
商品编号：
AG-25T-0109-C025
品牌：
Adipogen Inc
市场价：
¥9600.00
美元价：
5760.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Vasodilator-stimulatedPhosphoprotein |
| ProductType | PolyclonalAntibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | RecombinanthumanVASPfusedtoaHis-tag. |
| Application | Immunocytochemistry:(formaldehydefixedcells;1:250) Immunoprecipitation:(1:125) WesternBlot:1:2500 Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Human Mouse Pig |
| Specificity | Recognizesboththe46kDa(Ser157dephospho-)and50kDa(Ser157phospho-)formofhuman,mouseandporcineVASP. |
| Purity | Antigenaffinitypurified. |
| Concentration | 250µg/ml |
| Formulation | Liquid.InPBScontaining1mg/mlBSAand0.02%sodiumazide. |
| OtherProductData | ContainsPositiveControl:Humanplateletprotein(500µg)(Prod.No.AG-35T-0001),suppliedat5mg/mlinSDS-stopsolution(100mMNaCl,73mMTris/HClpH6.7,10mMDTT,8mMEDTA,5%[v/v]glycerol,2%[w/v]SDS,10μg/mlbromophenolbluesodiumsalt).Use5μl(25μg)perlane. |
| AccessionNumber | UniProtIDP50552:VASP |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
VASP(vasodilator-stimulatedphosphoprotein)isaproline-richproteinsubstrateofcAMP-andcGMP-dependentproteinkinases.VASPisanactin-associatedproteininvolvedinarangeofprocessesdependentonCytoskeletonremodelingandcellpolaritysuchasaxonguidance,lamellipodialandfilopodialdynamics,plateletactivationandcellmigration.VASPpromotesactinfilamentelongation.Itprotectsthebarbedendofgrowingactinfilamentsagainstcappingandincreasestherateofactinpolymerizationinthepresenceofcappingproteins.VASPstimulatesactinfilamentelongationbypromotingthetransferofprofilin-boundactinmonomersontothebarbedendofgrowingactinfilamentsanditplaysaroleinactin-basedmobilityofListeriamonocytogenesinhostcells.Itregulatesactindynamicsinplateletsandplaysanimportantroleinregulatingplateletaggregation.VASPphosphorylationisusedtomonitortheeffectofso-calledantiplateletdrugsthatreduceplateletreactivityandareusedtopreventstentthrombosis,strokesandheartattacksinpatients.PhosphorylationofVASPatSer157causesamobilityshiftinSDSgelelectrophoresisfrom46to50kDa,whichhasbeenusedasaconvenientMarkertomonitorcyclicnucleotide-dependentproteinkinaseactivity.
ProductReferences
- Mechanicalforcesfacilitateactinpolymerizationatfocaladhesionsinazyxin-dependentmanner:H.Hirata,etal.;J.CellSci.121,2795(2008)
- VASPisinvolvedincAMP-mediatedRac1activationinmicrovascularendothelialcells:N.Schlegel,&J.Waschke;Am.J.Physiol.Cell.Physiol.296,C453(2009)
- Nitro-fattyacidsreduceatherosclerosisinapolipoproteinE-deficientmice:T.K.Rudolph,etal.;Arterioscler.Thromb.Vasc.Biol.30,938(2010)
- TheEps8/IRSp53/VASPNetworkDifferentiallyControlsActinCappingandBundlinginFilopodiaFormation:F.Vaggi,etal.;PLoSComput.Biol.7,e1002088(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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