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Functional_antibody >
Adipogen/anti-Ubiquitin (human), mAb (83406)/AG-20T-0208-C050/50 µg
| ProductDetails | |
|---|---|
| Synonyms | UBB;UbiquitinB |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 83406 |
| Isotype | MouseIgG2b |
| Immunogen/Antigen | Synthetichumanubiquitin+1peptide. |
| Application | WesternBlot(0.1-0.5µg/ml) |
| Crossreactivity | Human |
| Specificity | RecognizeshumanUbiquitinandUbiquitin+1. |
| PurityDetail | ProteinAorGpurified. |
| Formulation | Liquid.InPBS,pH7.4,50%glycerol,0.09%sodiumazide. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ubiquitinisa76aminoacid(aa)proteinthatisubiquitouslyexpressedinalleukaryoticorganisms.ubiquitinishighlyconservedwith96%aasequenceidentitysharedbetweenhumanandyeastubiquitin,and100%aasequenceidentitysharedbetweenhumanandmouseubiquitin.Inmammals,fourubiquitingenesencodefortwoubiquitin-ribosomalfusionproteinsandtwopoly-ubiquitinproteins.Cleavageoftheubiquitinprecursorsbydeubiquitinatingenzymesgivesrisetoidenticalubiquitinmonomerseachwithapredictedmolecularweightof8.6kDa.ConjugationofubiquitintotargetproteinsinvolvestheformationofanisopeptidebondbetweentheC-terminalglycineresidueofubiquitinandalysineresidueinthetargetprotein.Thisprocessofconjugation,referredtoasubiquitinationorubiquitylation,isamulti-stepprocessthatrequiresthreeenzymes:aubiquitin-activating(E1)enzyme,aubiquitin-conjugating(E2)enzyme,andaubiquitinligase(E3).ubiquitinationisclassicallyrecognizedasamechanismtotargetproteinsfordegradationandasaresult,ubiquitinwasoriginallynamedATP-dependentProteolysisFactor1(APF-1).Inadditiontoproteindegradation,ubiquitinationhasbeenshowntomediateavarietyofBIOLOGicalprocessessuchassignaltransduction,endocytosis,andpost-endocyticsorting.
