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Adipogen/anti-TRIF (human), pAb (AL227)/AG-25B-0008-C050/50 µg
Adipogen/anti-TRIF (human), pAb (AL227)/AG-25B-0008-C050/50 µg
商品编号：
AG-25B-0008-C050
品牌：
Adipogen Inc
市场价：
¥4200.00
美元价：
2520.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Toll-interleukin-1Receptor[TIR]Domain-containingAdapterInducingInterferon-β;TICAM-1;TIR-containingAdaptorMolecule-1 |
| ProductType | PolyclonalAntibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Syntheticpeptidecorrespondingtoaa4-31(T4GPSLPSAFDILGAAGQDKLLYLKHKLK31)ofN-terminalhumanTRIF. |
| Application | Immunoprecipitation WesternBlot:(1:1"000) |
| Crossreactivity | Human |
| Specificity | RecognizeshumanTRIF. |
| PurityDetail | ProteinA-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
TRIFisinvolvedininnateimmunityagainstinvADIngpathogens.ItisanadaptorusedbyTLR3andTLR4(throughTICAM-2)tomediateNF-κBandinterferon-regulatoryfactor(IRF)activationandtoinduceapoptosis.LigandbindingtoTLR3andTLR4resultsinTRIFrecruitmentthroughitsTIRdomain.Distinctprotein-interactionmotifsallowrecruitmentoftheeffectorproteinsTBK1,TRAF6andRIPK1,whichinturn,leadtotheactivationoftranscriptionfactorsIRF3andIRF7,NF-κBandFADDrespectively.TRIFisubiquitouslyexpressedwithhigherlevelsinliver.
ProductReferences
- ThehumanadaptorSARMnegativelyregulatesadaptorproteinTRIF-dependentToll-likereceptorsignaling:M.Carty,etal.;Nat.Immunol.7,1074(2006)
- Interferonregulatoryfactor3-dependentresponsestolipopolysaccharideareselectivelybluntedincordbloodcells:E.Aksoy,etal.;Blood109,2887(2007)
- TheantiviraladaptorproteinsCardifandTrifareprocessedandinactivatedbycaspases:M.Rebsamen,etal.;CellDeathDiffer.15,1804(2008)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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