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Adipogen/anti-TRAIL-R2 (human), mAb (TR2.21)/AG-20B-0028-C100/100 µg
Adipogen/anti-TRAIL-R2 (human), mAb (TR2.21)/AG-20B-0028-C100/100 µg
商品编号：
AG-20B-0028-C100
品牌：
Adipogen Inc
市场价：
¥7400.00
美元价：
4440.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | TRAILReceptor2;DR5;KILLER;TNFRSF10B;CD262 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | TR2.21 |
| Isotype | MouseIgG1 |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | RecombinanthumanTRAIL-R2(DR5). |
| Application | FlowCytometry Immunohistochemistry:(paraffinsections)(20μg/ml) Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Human |
| Specificity | RecognizeshumanTRAIL-R2.Doesnotcross-reactwithhumanTRAIL-R1,-R3or-R4. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| OtherProductData | SpeciallydevelopedfortheimmunohistochemicaldetectionofTRAIL-R2inparaffinembeddedtissue.HasbeenshowntodetectTRAIL-R2expressedatendogenouslevelsinparaffin-embeddedtissueindifferentmammarycarcinomatissues.ForIHC(paraffinsections)TRAIL-R2specificstainingprotocol(seePDFonweb). UniProtlinkO14763:humanTRAIL-R2 |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| Protocols |  DownloadPDF |
| MSDS | DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
TRAIL-R2isareceptorforthecytotoxicligandTRAIL.TheadaptermoleculeFADDrecruitscaspase-8totheactivatedreceptor.Theresultingdeath-inducingsignalingcomplex(DISC)performscaspase-8proteolyticactivationwhichinitiatesthesubsequentcascadeofcaspases(aspartate-specificcysteineproteases)mediatingapoptosis.PromotestheactivationofNF-κB.
ProductReferences
- TRAIL/bortezomibcotreatmentispotentiallyhepatotoxicbutinducescancer-specificapoptosiswithinatherapeuticwindow:R.Koschny,etal.;Hepatol.45,649(2007)
- Troglitazone-mediatedsensitizationtoTRAILinducedapoptosisisregulatedbyproteasomedependentdegradationofFLIPandERK1/2-dependentphosphorylationofBAD:K.Grund,etal.;CancerBiol.Ther.7,1982(2008)
- Prognosticsignificanceoftumournecrosisfactor-relatedapoptosis-inducingligand(TRAIL)receptorexpressioninpatientswithbreastcancer:T.M.Ganten,etal.;J.Mol.Med.87,995(2009)
- PrognosticValueofTumorNecrosisFactor-RelatedApoptosis-InducingLigand(TRAIL)andTRAILReceptorsinRenalCellCancer:S.Macher-Goeppinger,etal.;Clin.CancerRes.15,650(2009)
- Cytosolicandnuclearcaspase-8haveoppositeimpactonsurvivalafterliverresectionforhepatocellularcarcinoma:R.Koschny,etal.;BMCCancer13,532(2013)
- Cancercell-autonomousTRAIL-RsignalingpromotesKRAS-drivencancerprogression,invasion,andmetastasis:S.vonKarstedt,etal.;CancerCell27,561(2015)
- IAPscauseresistancetoTRAIL-dependentapoptosisinfollicular1thyroidcancer:T.A.Werner,etal.;Endocr.Relat.Cancer17,0479(2018)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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