脂肪原/抗TRAIL-R1（人），单克隆抗体（HS101）（FITC）/AG-20B-0022F-T100/100试验
商品编号：
AG-20B-0022F-T100
品牌：
Adipogen Inc
市场价：
¥8000.00
美元价：
4800.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | TRAILReceptor1;DR4;APO2;TNFRSF10A;CD261 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | HS101 |
| Isotype | MouseIgG1 |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | RecombinanthumanTRAIL-R1(DR4). |
| Label/Conjugates | FITC |
| Application | FlowCytometry Immunocytochemistry Definitionfor1test:1μloflabeledantibodyin200μlofFlowCytometrybuffer(seeonlineprotocol). |
| Crossreactivity | Human |
| Specificity | RecognizeshumanTRAIL-R1.Doesnotcross-reactwithhumanTRAIL-R2,-R3or-R4. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Donotfreeze. Protectfromlight. |
| Use/StABIlity | Keepconjugatedformatsat+4°C. Stableforatleast1yearafterreceiptwhenstoredat+4°C. |
| Documents | |
| Protocols |  DownloadPDF |
| MSDS | DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
TRAIL-R1isareceptorforthecytotoxicligandTRAIL.TheadaptermoleculeFADDrecruitscaspase-8totheactivatedreceptor.Theresultingdeath-inducingsignalingcomplex(DISC)performscaspase-8proteolyticactivationwhichinitiatesthesubsequentcascadeofcaspases(aspartate-specificcysteineproteases)mediatingapoptosis.PromotestheactivationofNF-κB.
ProductReferences
- Caspase-10isrecruitedtoandactivatedatthenativeTRAILandCD95death-inducingsignallingcomplexesinaFADD-dependentmannerbutcannotfunctionallysubstitutecaspase-8:M.R.Sprick,etal.;EMBOJ.21,4520(2002)
- Mitogen-ActivatedProteinKinase/ExtracellularSignal-RegulatedKinaseSignalinginActivatedTCellsAbrogatesTRAIL-InducedApoptosisUpstreamoftheMitochondrialAmplificationLoopandCaspase-8:T.S.Soderstrom,etal.;J.Immunol.169,2851(2002)
- ProteasomeinhibitionresultsinTRAILsensitizationofprimarykeratinocytesbyremovingtheresistance-mediatingblockofeffectorcaspasematuration:M.Leverkus,etal.;Mol.Cell.Biol.23,777(2003)
- TNF-RelatedApoptosis-InducingLigandMediatesTumoricidalActivityofHumanMonocytesStimulatedbyNewcastleDiseaseVirus:B.Washburn,etal.;J.Immunol.170,1814(2003)
- TRAILregulatesnormalerythroidmaturationthroughanERK-dependentpathway:P.Secchiero,etal.;Blood 103,517(2004)
- IFN{alpha}-stimulatedneutrophilsandmonocytesreleaseasolubleformofTNF-relatedapoptosis-inducingligand(TRAIL/Apo-2ligand)displayingapoptoticactivityonleukemiccells:C.Tecchio,etal.;Blood103,3837(2004)
- Enhancedcaspase-8recruitmenttoandactivationattheDISCiscriticalforsensitisationofhumanhepatocellularcarcinomacellstoTRAIL-inducedapoptosisbychemotherapeuticdrugs:T.M.Ganten,etal.;CellDeathDiffer.11Suppl1,86(2004)
- CaseinkinaseIattenuatestumornecrosisfactor-relatedapoptosis-inducingligand-inducedapoptosisbyregulatingtherecruitmentoffas-associateddeathdomainandprocaspase-8tothedeath-inducingsignalingcomplex:K.Izeradjene,etal.;CancerRes.64,8036(2004)
- cFLIPLinhibitstumornecrosisfactor-relatedapoptosis-inducingligand-mediatedNF-kappaBactivationatthedeath-inducingsignalingcomplexinhumankeratinocytes:T.Wachter,etal.;J.Biol.Chem.279,52824(2004)
- ResistancetoFasLandtumornecrosisfactor-relatedapoptosis-inducingligand-mediatedapoptosisinSezarysyndromeT-cellsassociatedwithimpaireddeathreceptorandFLICE-inhibitoryproteinexpression:E.Contassot,etal.;Blood111,4780(2008)
- TRAIL-R2-specificantibodiesandrecombinantTRAILcansynergisetokillcancercells:M.H.Tuthill,etal.;Oncogene34,2138(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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