Adipogen/anti-TNF-α, mAb (6C10)/YIF-LF-MA0210/100 µl
商品编号：
YIF-LF-MA0210
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | TNF;TNFA |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 6C10 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanGFP-TNF-αproteinpurifiedfromE.coli. |
| Application | ELISA WesternBlot(1:2,000) |
| Crossreactivity | Human |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Tumornecrosisfactor(TNF)-αisanimportantcytokineintheinnateimmuneresponseproducedbymacrophages,neutrophils,fibroblasts,keratinocytes,NKcells,TandBcells,andtumourcells.TNF-αmediateshostresponsesinacuteandchronicinflammatoryconditions,andisamediatorofprotectionfrominfectionandmalignancy.TNF-αcausesapoptoticcelldeath,cellularproliferation,differentiation,inflammation,tumOrigenesis,andviralreplication.TNF-αisinitiallyproducedasaBIOLOGicallyactive26kDatransmembraneprotein,whichissubsequentlycleaved,principallybyTNF-α-convertingenzyme(TACE),toreleasethe17kDafreeprotein.TheseproteinsarearrangedinbiologicallyactivehomotrimersthatactontheubiquitouslyexpressedTNF-αreceptors1and2(TNFR1andTNFR2).These17kDaTNFprotomersarecomposedoftwoantiparallelβ-pleatedsheetswithantiparallelβ-strands,forminga"jellyroll"β-structure,typicalfortheTNFfamily.TNF-R1isconstitutivelyexpressedinmosttissues,andcanbefullyactivatedbyboththemembrane-boundandsolubletrimericformsofTNF,whileTNF-R2isonlyfoundincellsoftheimmunesystemandrespondtothemembrane-boundformoftheTNFhomotrimer.Althoughtheirextracellulardomainssharestructuralandfunctionalhomology,theirintracellulardomainsaredistinct.Tumornecrosisfactorpromotestheinflammatoryresponse,whichinturncausesmanyoftheclinicalproblemsassociatedwithautoimmunedisorderssuchasrheumatoidarthritis,ankylosingspondylitis,Crohn"sdisease,psoriasisandrefractoryasthma.ThesedisordersaresometimestreatedbyusingTNFinhibitorssuchasinfliximab(Remicade)oradalimumab(Humira).CytokinethatbindstoTNFRSF1A/TNFR1andTNFRSF1B/TNFBR.Itismainlysecretedbymacrophagesandcaninducecelldeathofcertaintumorcelllines.Itispotentpyrogencausingfeverbydirectactionorbystimulationofinterleukin-1secretionandisimplicatedintheinductionofcachexia,Undercertainconditionsitcanstimulatecellproliferationandinducecelldifferentiation.
ProductReferences
1)BerryM,etal.(2007)CurrOpinPharmacol.7(3):279-282.(General)
2)AndersonGM,etal.(2004)CurrOpinPharmacol.4(4):314-320.(General)
3)PallADInoMA,etal.(2003)NatureReviewsDrugDiscovery.2:736-746.(General)
2)AndersonGM,etal.(2004)CurrOpinPharmacol.4(4):314-320.(General)
3)PallADInoMA,etal.(2003)NatureReviewsDrugDiscovery.2:736-746.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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