当前位置：
首页
>
产品中心 >
Functional_antibody >
Adipogen/anti-TLR8 (human), mAb (ABM15F6)/AG-20T-0307-C100/100 µg
Adipogen/anti-TLR8 (human), mAb (ABM15F6)/AG-20T-0307-C100/100 µg
商品编号：
AG-20T-0307-C100
品牌：
Adipogen Inc
市场价：
¥7200.00
美元价：
4320.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Toll-likeReceptor8;CD288 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | ABM15F6 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanTLR8protein(aa750-900). |
| Application | FlowCytometry:(0.5-2μg/106cells) Immunohistochemistry:(5μg/ml;paraffinsections) Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Human |
| Specificity | RecognizeshumanTLR8. |
| Purity | ProteinGpurified. |
| Concentration | 0.5mg/ml |
| Formulation | Liquid.InPBScontaining0.05%BSAand0.05%sodiumazide. |
| Declaration | Q9NR97 |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Stableforatleast6monthsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
TLR8(Toll-likeReceptor8)isamemberoftheTLR(Toll-likereceptor)familythatplaysafundamentalroleinpathogenrecognitionandactivationofinnateimmunity.TLR8isanucleotide-sensingTLR.TLR8andTLR7recognizesingle-strandedRNA(ssRNA)sequencescontainingGU-richorpoly-Usequencesastheirnaturalligands,andtheyarealsoactivatedbysyntheticsmall-molecular-weightcompoundsoftheimidazoquinolinefamily.BothTLR8andTLR7signalviaMYD88andTRAF6,leADIngtoNF-κBandantiviralfactor,suchasIRFfamilyactivation,cytokinesecretionandtheinflammatoryresponse.Theyarelocalizedintracellularlytoendosomalmembranesandactaspotentactivatorsofinnateimmuneresponsesuponviralinfection.TheTLR8geneispredominantlyexpressedinlungandperipheralbloodleukocytesandliesincloseproximitytoTLR7onchromosomeX.GeneticvariantsinTLR8havebeenlinkedtosusceptibilitytopulmonarytuberculosis.Recently,smallmoleculeTLR7/8agoNISTshavedemonstratedpotentialasvaccineadjuvants,sincetheydirectlyactivateantigen-presentingcells(APCs)andcanenhancebothhumoralandcellularimmuneresponses,especiallyTh1responses.ThismakestheTLR7/8signalingpathwaysinterestingtherapeutictargets.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
