脂肪原/抗Syk，单克隆抗体（12E3）/YIF-LF-MA0239/100µl
商品编号：
YIF-LF-MA0239
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SYK;p72-Syk;EC=2.7.10.2;SpleenTyrosineKinase;Tyrosine-ProteinKinaseSYK |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 12E3 |
| Isotype | MouseIgG2bκ |
| Immunogen/Antigen | Syntheticpeptide. |
| Application | WesternBlot(1:1,000) Immunoprecipitation(2μl) |
| Crossreactivity | Human |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Syk,Spleentyrosinekinase,isexpressedinawiderangeofhematopoieticandnon-hematopoieticcellsandplaysakeyroleinadaptiveimmunesystem,whichistheimmunoreceptor(BcellreceptorandFc-receptors)signalingpathwaysincludingFcγreceptor-mediatedphagocytosis.InhematopoieticcellssuchasBandTlymphocytes,naturalkillercells,mastcells,macrophagesandplatelets,Sykisinvolvedintheproximalsignalingdownstreamofactivatedimmunoreceptors(e.g.BCR,TCR,Fcreceptors)containingimmunoreceptortyrosine-basedactivationmotifs(ITAMs)towhichitbindsusingitstandemSH2domains.ActivatedandautophosphorylatedSykthenphosphorylatesitsspecificsubstratesincludingotherenzymesandadaptorproteins,orchestratingacomplexseriesofcellularresponsessuchascellproliferation,differentiation,survivalandphagocytosis.PositiveeffectorofBCR-stimulatedresponses.CouplestheB-cellantigenreceptor(BCR)tothemobilizationofcalciumioneitherthroughaphosphoinositide3-kinase-dependentpathway,whennotphosphorylatedontyrosinesofthelinkerregion,orthroughaphospholipaseC-γ-dependentpathway,whenphosphorylatedonTyr-348andTyr-352.ThusthedifferentialphosphorylationofSykcandeterminethepathwaybywhichBCRiscoupledtotheregulationofintracellularcalciumion
ProductReferences
1)TurnerM,etal,ImmunolToday.2000;vol.21(3):148-154.(General)
2)BertonG,etal,TrendsImmunol.2005;vol.26(4):208-214.(General)
3)CoopmanPJ,MuellerSC.CancerLett.2006;vol.241(2):159-173.(General)
4)NavaraCSCurrPharmDes.2004;vol.10(15):1739-1744.(General)
2)BertonG,etal,TrendsImmunol.2005;vol.26(4):208-214.(General)
3)CoopmanPJ,MuellerSC.CancerLett.2006;vol.241(2):159-173.(General)
4)NavaraCSCurrPharmDes.2004;vol.10(15):1739-1744.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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