Adipogen/anti-SHP1, mAb (14D5)/YIF-LF-MA0212/100 µl
商品编号：
YIF-LF-MA0212
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | HCP;PTPN6;PTP-1C;SH-PTP1;EC=3.1.3.48;Protein-TyrosinePhosphatase1C;Protein-TyrosinePhosphataseSHP-1;HematopoieticCellProtein-TyrosinePhosphatase;Tyrosine-ProteinPhosphataseNon-ReceptorType6 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 14D5 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanHis/ABD-SHP1proteinpurifiedfromE.coli. |
| Application | ELISA WesternBlot(1:2,000) |
| Crossreactivity | Human |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
SHP1andSHP2representasubfamilyofnon-transmembraneprotein-tyrosinephosphatases(PTPs)thatcontaintwotandemSH2(srchomology2)domains.SHPshavetwoN-terminalSH2domains(N-SH2andC-SH2),aclassicPTPdomainandaC-terminaltailharboringtwotyrosylphosphorylationsiteswhicharephosphorylateddifferentiallybyreceptorandnon-receptorprotein-tyrosinekinases(PTKs).WhereasSHP2isexpressedubiquitously,SHP1isprimarilyexpressedinhematopoieticcellsandbehavesasakeyregulatorcontrollingintracellularphosphotyrosinelevelsinlymphocytes.SH2domains(particularlytheN-SH2)alsoregulatePTPactivity.BasalSHPactivityislow,butadditionofaphosphotyrosylpeptidethatbindstheN-SH2(Tyr–Ppeptideligand)markedlystimulatescatalysis.SHP1isimplicatedinsignalingfromreceptortyrosinekinases(RTKs),cytokinereceptors,chemokinereceptorsandintegrins.SHP1-deficientbonemarrowmacrophagesarehyper-adherenttoβ1-andβ2-integrinligands.DecreasedSHP1levelcausesabnormalT-lymphocyteproliferationandinducesvarioustypesofleukemias.IntroductionoftheSHP1genebackintoaleukemiacelllineandaprostatecancercelllinedemonstratedthetumorsuppressorfunctionofSHP1.Playsakeyroleinhematopoiesis.ThisPTPaseactivitymaydirectlylinkgrowthfactorreceptorsandothersignalingproteinsthroughprotein-tyrosinephosphorylation.TheSH2regionsmayinteractwithothercellularcomponentstomodulateitsownphosphataseactivityagainstinteractingsubstrates.TogetherwithMTUS1,inducesUBE2V2expressionuponangiotensinIIstimulation.
ProductReferences
1)HonoratJFetal.,(2006)Blood.107(10):4130-4138.(General)
2)NeelBGetal.,(2003)TrendsBiochemSci.28:284-293.(General)
3)WuCetal.(2003)Gene.306:1-12.(General)
2)NeelBGetal.,(2003)TrendsBiochemSci.28:284-293.(General)
3)WuCetal.(2003)Gene.306:1-12.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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