Adipogen/anti-Shc1, mAb (47F4)/YIF-LF-MA0201/100 µl
商品编号：
YIF-LF-MA0201
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SHC;SHC1;SH2DomainProteinC1;SHC-transformingProteinA;SHC-transformingProtein3;SHC-transformingProtein1;SrcHomology2Domain-containing-transformingProteinC1 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 47F4 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanHis/ABD-Shc1proteinpurifiedfromE.coli. |
| Application | ELISA WesternBlot(1:5,000) Immunoprecipitation(1μl) |
| Crossreactivity | Human Mouse Rat |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
ShcisaprototypeadapterproteinthatisexpressedfromtheearlieststagesofT-celldevelopment.ShcbecomesrapidlytyrosinephosphorylatedafterT-cellreceptor(TCR)engagement.ThreeshcgeneshavebeenidentifiedinmammalsandtheirgeneproductshavebeenreferredtoasShcA,ShcBandShcC.ShcAisubiquitouslyexpressed,whileshcBandShcCexpressionappearlimitedtoneuronalcells.ShcAisexpressedasthreeisoformsofabout46,52and66kDa.ShciscomposedofanN-terminalPTB,acentralcollagen-homology(CH)domainandaC-terminalSH2domain.The66kDaisoformofShcAisexpressedinmostcellsexceptinthehematopoieticlineageandcontainsanadditionalamino-terminalCH-likeregion.ThetyrosinephosphorylationofShchasbeennoticeduponengagementofnumerouscellsurfacereceptorssuchasgrowthfactorreceptors,antigenreceptors,cytokinereceptors,G-proteincoupledreceptorsandhormonereceptors.TheinvolvementofShcAintheRassignalingpathwayisinitiatedbythetyrosine-phosphorylationofthereceptorproteintyrosinekinases(RPTKs)andsubsequentinteractionwithGrb2andRasguaninenucleotideexchangefactor,Sos.TheShc:Grb2:SoscomplexgetslocalizedtothemembranethroughtheinteractionofShcwiththephosphorylatedreceptor.Membrane-boundSosthenactivatesRasbycatalysingGDP/GTDexchange.GTP-boundRasthentriggersdownstreamevents,whichincludeRaf,themitogen-activatedproteinkinases(MAPKs)andMAPKkinase(MEK).Signalingadapterthatcouplesactivatedgrowthfactorreceptorstosignalingpathway.Isoformp46Shcandisoformp52Shc,oncephosphorylated,coupleactivatedreceptortyrosinekinasestoRasviatherecruitmentoftheGRB2/SOScomplexandareimplicatedinthecytoplasmicpropagationofmitogenicsignals.Isoformp46Shcandisoformp52ShcmaythusfunctionasinitiatorsoftheRassignalingcascadeinvariousnon-neuronalsystems.Isoformp66ShcdoesnotmediateRasactivation,butisinvolvedinsignaltransductionpathwaysthatregulatethecellularresponsetooxidativestressandlifespan.Isoformp66Shcactsasadownstreamtargetofthetumorsuppressorp53andisindispensablefortheabilityofstress-activatedp53toinduceelevationofintracellularoxidants,cytochromecreleaseandapoptosis.Theexpressionofisoformp66Shchasbeencorrelatedwithlifespan.
ProductReferences
1)ZhangL,LorenzUandRavichandranKS.,(2003)ImmunolRev.191:183-95.(General)
2)RavichandranKS.,(2001)Oncogene.20(44):6322-30.(General)
3)CattaneoEandPelicciPG.,(1998)TrendsNeurosci.21(11):476-81.(General)
2)RavichandranKS.,(2001)Oncogene.20(44):6322-30.(General)
3)CattaneoEandPelicciPG.,(1998)TrendsNeurosci.21(11):476-81.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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