Adipogen/anti-RIG-I, mAb (Alme-1)/AG-20B-0009-C100/100 µg
商品编号：
AG-20B-0009-C100
品牌：
Adipogen Inc
市场价：
¥7900.00
美元价：
4740.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | RIG-1;RetinoicAcid-inducIBLeGene1Protein;DEAD-boxProtein58;ProbableATP-dependentRNAHelicaseDDX58 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | Alme-1 |
| Isotype | MouseIgG1 |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | RecombinanthumanRIG-I(aa201-713). |
| Application | Immunohistochemistry:(paraffinsections) Immunoprecipitation:(1:200) Westernblot:(1:1’000) |
| Crossreactivity | Human Mouse |
| Specificity | RecognizeshumanandmouseRIG-I. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
RIG-IandMDA5arehighlyconservedhelicasesinvolvedintheinnateimmuneresponsetovirus.RIG-IisamemberoftheDEAD-boxRNAhelicasesandisactivatedbycytoplasmicdsRNAand5’-pppRNAproducedduringtheviralreplication.TheproteinischaracterizedbyaN-terminalregionwithtwocaspaserecruitmentdomains(CARD)andaC-terminalregionharboringpotentialATP-dependentRNAhelicaseactivity.RIG-IrecruitstheCARDadaptorinducingIFN-β(Cardif)inaCARD-CARD-dependentmannerresultinginNF-κBandIRF3activation.
ProductReferences
- TheantiviraladaptorproteinsCardifandTrifareprocessedandinactivatedbycaspases:M.Rebsamen,etal.;CellDeathDiffer.15,1804(2008)
- Phosphorylation-mediatednegativeregulationofRIG-Iantiviralactivity:M.U.Gack,etal.;J.Virol.84,3220(2010)
- IncomingRNAVirusNucleocapsidsContaininga5"-TriphosphorylatedGenomeActivateRIG-IandAntiviralSignaling:M.Weber,etal.;CellHostMicrobe13,336(2013)
- Lymphocyticchoriomeningitisvirusdifferentiallyaffectsthevirus-inducedtypeIinterferonresponseandmitochondrialapoptosismediatedbyRIG-I/MAVS:C.Pythoud,etal.;J.Virol.89,6240(2015)
- Aphosphomimetic-basedmechanismofdenguevirustoantagonizeinnateimmunity:Y.K.Chan&M.U.Gack;Nat.Immunol.17,523(2016)
- SensingoflatentEBVinfectionthroughexosomaltransferof5"pppRNA:S.R.Baglio,etal.;PNAS113,E587(2016)
- RNAsContainingModifiedNucleotidesFailToTriggerRIG-IConformationalChangesforInnateImmuneSignaling:A.FiegenDurbin,etal.;MBio7,e00833(2016)
- Viralunmaskingofcellular5SrRNApseudogenetranscriptsinducesRIG-I-mediatedimmunity:J.J.Chiang,etal.;Nat.Immunol.aheadofprint(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
