Adipogen/anti-RasGRP2, pAb (IG-09)/AG-25T-0118-R100/100 µl
商品编号：
AG-25T-0118-R100
品牌：
Adipogen Inc
市场价：
¥9200.00
美元价：
5520.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CalDAG-GEFI;RasGuanylNucleotide-releasingProtein2;RasGuanylReleasingProtein2;CDC25-likeProtein;CDC25L;CalciumandDAG-regulatedGuanineNucleotideExchangeFactorI;MCG7 |
| ProductType | PolyclonalAntibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | SyntheticpeptidecorrespondingtoahumanRasGRP2sequencelocatedattheC-terminusoftheRasGEFdomain. |
| Application | WesternBlot:(1:4"000-1:8"000) Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Human Mouse |
| Specificity | RecognizeshumanandmouseRasGRP2. |
| Purity | Antigenaffinitypurified. |
| Formulation | Liquid.InPBScontaining2mg/mlBSAand0.05%sodiumazide. |
| OtherProductData | UniProtIDQ7LDG7:RasGRP2(human) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Donotfreeze. Keepsterile. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
RasGRP2functionsasacalcium-andDAG-regulatednucleotideexchangefactorspecificallyactivatingsmallGTPases,includingRap1/RAS3,throughtheexchangeofboundGDPforGTP.ItmayalsoactivateotherGTPasessuchasRRAS,RRAS2,NRAS,KRASbutnotHRAS.Theproteinisexpressedinplatelets,neutrophilsandTlymphocytes.RasGRP2functionsinaggregationofplateletsandadhesionofTlymphocytesandneutrophilsprobablythroughinside-outintegrinactivation.S587wasidentifiedasthemajorPKAphosphorylation.PhosphorylationofS587correlatedwiththeinhibitoryeffectofPKAonRap1bactivationinplatelets.Invitro,ERK1/2phosphorylatesRasGRP2atSer394tolimititsexchangeactivityandinhibitsitsabilitytoactivatethesmallGTPaseRap1thatultimatelyleadstodecreasedactivationofERK1/2incells.
ProductReferences
- PhosphorylationofCalDAG-GEFIbyproteinkinaseApreventsRap1bactivation:H.Subramanian,et.al.;Thromb.Haemost.11,1574(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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