脂肪原/抗Rab1-GTP，单克隆抗体（rec.）（ROF7）/AG-27B-0006-C100/100µg
商品编号：
AG-27B-0006-C100
品牌：
Adipogen Inc
市场价：
¥6500.00
美元价：
3900.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Ras-relatedProteinRab-1 |
| ProductType | RecombinantAntibody |
| Properties | |
| Clone | ROF7 |
| Isotype | HumanIgG2&lamBDa; |
| Source/Host | Purifiedfrom HEK293cell culturesupernatant. |
| Immunogen/Antigen | FulllengthcanineRab1. |
| Application | Immunocytochemistry:(1:1000) Immunoprecipitation:(1:200) |
| Crossreactivity | Dog Human Mouse Rat |
| Specificity | Recognizeshuman,mouse,ratanddogRab1a-GTPandRab1b-GTP. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinA-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| OtherProductData | anti-Rab1-GTP,monoclonalantibody(recombinant)(ROF7)iscomposedofhumanvariableregions(VHandVL)(λ-chain)ofimmunoglobulinfusedtothehumanlgG2Fcdomain. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1monthafterreceiptwhenstoredat+4°C. Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Rab1(Ypt1inyeast)isasmallGTPasethatplaysawell-establishedroleinmediatingER-to-Golgiproteintransportinbothyeastandmammaliancells.Rab1recruitseffectorproteinstobuddingCOPIIvesiclesattheER,formingcis-SNAREcomplexesthatpromotetargetingtoandfusionofthesevesicleswiththecis-Golgi.Rab1isalsoinvolvedinCOPIvesicleformationandotherdistincttransportpathways,includingER-to-Golgiintermediatecompartment(ERGIC)-to-cellperipherytrafficking.RecentlyRab1hasbeenshowntofunctioninantimicrobialautophagy(autophagosomeformation),aswellasotherformsofautophagyinmammaliancellsinawayindependentofER-to-Golgitrafficking.
anti-Rab1-GTP,monoclonalantibody(recombinant)(ROF7)isanantibodydevelopedbyantibodyphagedisplaytechnologyusingahumannaiveantibodygenelibrary.TheselibrariesconsistofscFv(singlechainfragmentvariable)composedofVH(variabledomainofthehumanimmunoglobulinheavychain)andVL(variabledomainofthehumanimmunoglobulinlightchain)connectedbyapolypeptidelinker.Theantibodyfragmentsaredisplayedonthesurfaceoffilamentousbacteriophage(M13).ThisscFvwasselectedbyaffinityselectiononantigeninaprocesstermedpanning.Multipleroundsofpanningareperformedtoenrichforantigen-specificscFv-phage.Monoclonalantibodiesaresubsequentlyidentifiedbyscreeningaftereachroundofselection.TheselectedmonoclonalscFvisclonedintoanappropriatevectorcontainingaFcportionofinterestandthenproducedinmammaliancellstogenerateanIgGlikescFv-Fcfusionprotein.ProductReferences
- Characterizationofsinglechainantibodytargetsthroughyeasttwohybrid:O.Vielemeyer,etal.;BMCBiotechnol.10, 59(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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