Adipogen/anti-PTEN, mAb (16F3)/YIF-LF-MA0286/100 µl
商品编号：
YIF-LF-MA0286
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PTEN;MMAC1;EC=3.1.3.67;EC=3.1.3.16;EC=3.1.3.48;PhosphataseandTensinHomolog;MutatedinMultipleAdvancedCancers1;Phosphatidylinositol3;4;5-Trisphosphate3-PhosphataseandDual-SpecificityProteinPhosphatasePTEN |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 16F3 |
| Isotype | MouseIgG2aκ |
| Immunogen/Antigen | RecombinanthumanHis-PTENproteinpurifiedfromE.coli. |
| Application | ELISA WesternBlot(1:2,000) |
| Crossreactivity | Human Mouse Rat |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
PTENactsasaphosphatasetodephosphorylatephosphatidylinositol(3,4,5)-trisphosphate(PtdIns(3,4,5)P3).TheproductofthisenzymaticreactionisPtdIns(4,5)P2.ThisdephosphorylationisimportantbecauseitresultsininhibitionoftheAKTsignalingpathway.PTENisa403aminoacidprotein,andamemberofthelargePTP(proteintyrosinephosphatase)family.PTENcrystalstructurerevealedthattheN-terminalphosphatasedomainisfollowedbyatightlyassociatedC-terminalC2domain.Thesetwodomainstogetherformaminimalcatalyticunit.Thephosphatasedomaincontainstheactivesitewhichcarriesouttheenzymaticfunctionoftheprotein,whilsttheC2domainallowsPTENtobindtothephospholipidmembrane.PTENisoneofthemostcommonlylosttumoursuppressorsinhumancancer,anditsderegulationisalsoimplicatedinseveralotherdiseases.HereditarymutationofPTENcausestumor-susceptibilitydiseasessuchasCowdendisease.Tumorsuppressor.Actsasadual-specificityproteinphosphatase,dephosphorylatingtyrosine-,serine-andthreonine-phosphorylatedproteins.Alsoactsasalipidphosphatase,removingthephosphateintheD3positionoftheinositolringfromphosphatidylinositol3,4,5-trisphosphate,phosphatidylinositol3,4-diphosphate,phosphatidylinositol3-phosphateandinositol1,3,4,5-tetrakisphosphatewithorderofsubstratepreferenceinvitroPtdIns(3,4,5)P3>PtdIns(3,4)P2>PtdIns3P>Ins(1,3,4,5)P4.Thelipidphosphataseactivityiscriticalforitstumorsuppressorfunction.AntagonizesthePI3K-AKT/PKBsignalingpathwaybydephosphorylatingphosphoinositidesandtherebymodulatingcellcycleprogressionandcellsurvival.TheunphosphorylatedformcooperateswithAIP1tosuppressAKT1activation.Dephosphorylatestyrosine-phosphorylatedfocaladhesionkinaseandinhibitscellmigrationandintegrin-mediatedcellspreADIngandfocaladhesionformation.Maybeanegativeregulatorofinsulinsignalingandglucosemetabolisminadiposetissue.
ProductReferences
1)HamadaKetal.(2005)GenesDev19(17):2054–65.(General)
2)LeslieNRandDownesCP,(2004)BiochemJ382(Pt1):1–11.(General)
3)LiJetal.(1997)Science275(5308):1943–1947.(General)
2)LeslieNRandDownesCP,(2004)BiochemJ382(Pt1):1–11.(General)
3)LiJetal.(1997)Science275(5308):1943–1947.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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