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Adipogen/anti-pRb, mAb (Retinoblastoma Protein) (7E6)/YIF-LF-MA0172/100 µl
Adipogen/anti-pRb, mAb (Retinoblastoma Protein) (7E6)/YIF-LF-MA0172/100 µl
商品编号：
YIF-LF-MA0172
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Rb;pRb;RB1;pp110;p105-Rb;Retinoblastoma-associatedProtein |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 7E6 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanproteinpurifiedfromE.coli. |
| Application | ELISA WesternBlot(1:2,000) Immunoprecipitation(1μl) |
| Crossreactivity | Human |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
TheRbprotein(pRb,110kDa)isatumorsuppressor,whichplaysapivotalroleinthenegativecontrolofthecellcycleandintumorprogression.pRbisresponsIBLeforamajorG1checkpoint,blockingS-phaseentryandcellgrowth.pRbpreventsthecellfromreplicatingdamagedDNAbypreventingitsprogressionthroughthecellcycleintoitsSphaseorprogressingthroughG1phase.pRbcanactivelyinhibitcellcycleprogressionwhenitisdephosphorylatedwhilethisfunctionisinactivatedwhenpRbisphosphorylated.pRbisactivatedneartheendofmitosis(Mphase)whenaphosphatasedephosphorylatesit,allowingittobindE2F.ThepRbproteinrepressesgenetranscription,requiredfortransitionfromG1toSphase,bydirectlybindingtothetransactivationdomainofE2FandbybindingtothepromoterofthesegenesasacomplexwithE2F.Keyregulatorofentryintocelldivisionthatactsasatumorsuppressor.ActsasatranscriptionrepressorofE2F1targetgenes.Theunderphosphorylated,activeformofRB1interactswithE2F1andrepressesitstranscriptionactivity,leADIngtocellcyclearrest.Directlyinvolvedinheterochromatinformationbymaintainingoverallchromatinstructureand,inparticular,thatofconstitutiveheterochromatinbystabilizinghistonemethylation.RecruitsandtargetshistonemethyltransferasesSUV39H1,SUV420H1andSUV420H2,leadingtoepigenetictranscriptionalrepression.ControlshistoneH4"Lys-20"trimethylation.InhibitstheintrinsickinaseactivityofTAF1.Incaseofviralinfections,interactionswithSV40largeTantigen,HPVE7proteinoradenovirusE1AproteininducethedisassemblyofRB1-E2F1complextherebydisruptingRB1"sactivity.
ProductReferences
1)HickmanES,etal,CurrOpinGenetDev.(2002)vol.12(1):pp.60-6.(General)
2)YamasakiL,CancerTreatRes.(2003)vol.115:pp.209-39.(General)
3)GiacintiC,GiordanoA.Oncogene.(2006)vol.25(38):pp.5220-7.(General)
4)KhidrL,ChenPL.Oncogene.(2006)vol.25(38):pp.5210-9.(General)
2)YamasakiL,CancerTreatRes.(2003)vol.115:pp.209-39.(General)
3)GiacintiC,GiordanoA.Oncogene.(2006)vol.25(38):pp.5220-7.(General)
4)KhidrL,ChenPL.Oncogene.(2006)vol.25(38):pp.5210-9.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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