Adipogen/anti-PRAK, mAb (13H5)/YIF-LF-MA0195/100 µl
商品编号：
YIF-LF-MA0195
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | MK5;MK-5;PRAK;MAPKAPK5;MAPKAP-K5;MAPKAPK-5;EC=2.7.11.1;MAPKAPKinase5;MAPK-activatedProteinKinase5;MAPKinase-activatedProteinKinase5;p38-regulated/activatedProteinKinase |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 13H5 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanHis-PRAKproteinpurifiedfromE.coli. |
| Application | ELISA WesternBlot(1:5,000~10,000) |
| Crossreactivity | Human Mouse Rat |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
PRAKisa471aminoacidproteinwith20-30%sequenceidentitytotheknownMAPkinase-regulatedproteinkinasesRSK1/2/3,MNK1/2andMAPKAPK2/3.Thep38mitogen-activatedproteinkinase(MAPK)pathwayplaysanimportantroleincellularresponsestoinflammatorystimuliandenvironmentalstress.Thereareatleastsixproteinkinasesthatcanberegulatedbyp38αand/orp38β.Thesedownstreamkinasesofp38sincludeMAPK-activatedproteinkinase2(MAPKAPK2orMK2),MAPKAPK3,MAPK-interactingkinase1(MNK1),MNK2,p38-activated/regulatedproteinkinase(PRAKorMAPKAPK5),andmitogen-andstress-activatedproteinkinase(MSK).PRAKcanbeactivatedinresponsetocellularstressandproinflammatorycytokines.T182withintheactivationloopofPRAKhasbeendeterminedtobetheregulatoryphosphorylationsite.PRAKhasbeenreoprtedtobeessentialforras-inducedsenescenceandtumorsuppression.PRAKmediatessenescenceuponactivationbyp38inresponsetooncogenicras.Mediatesstress-inducedsmallheatshockprotein27phosphorylation.
ProductReferences
1)SunP.etal.,(2007)Cell.128:295-308.(General)
2)NewL.etal.,(1998)EMBOJ.17:3372-3384.(General)
2)NewL.etal.,(1998)EMBOJ.17:3372-3384.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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