Adipogen/anti-PP2A-α/β, mAb (13D4)/YIF-LF-MA0219/100 µl
商品编号：
YIF-LF-MA0219
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | RP-C;PPP2CA;PP2A-α;EC=3.1.3.16;ReplicationProteinC;Serine/Threonine-ProteinPhosphatase2ACatalyticSubunitαIsoform |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 13D4 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | Syntheticpeptide. |
| Application | WesternBlot(1:5,000) Immunoprecipitation(2~3μl) |
| Crossreactivity | Human Mouse Rat |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
ProteinPhosphatase2A(PP2A)isaubiquitousandconservedSerine/Threoninephosphataseandaccountsforalargefractionofphosphataseactivityineukaryoticcells.PP2Aplaysanimportantroleincellcycleregulation,cellgrowthcontrol,development,regulationofvarioussignaltransductionpathways,andcellmobility.PP2AcomprisesAandBsubunitswhichareregulatoryandacatalyticCsubunit.WhenthePP2AcatalyticCsubunit(36kDa)associateswiththeregulatoryA(65kDa,PR65)andBsubunits(PR55,PR56,PR72,PR93etc),widevarietyofheterotrimericholoenzymesareproducedwithdistinctfunctionsandcharacteristics.ThedifferentassociationofthesubunitsgivePP2Alargeregulatoryflexibilityanddifferentialsubstratespecificity.TheAsubunitexistsastwoisoforms(αandβ)asdoestheCsubunit,whereastheBsubunitsfallintothreefamiliesdesignatedB,B"(alsocalledB56),andB"".TheAsubunitisthescaffoldrequiredfortheformationoftheheterotrimericcomplexandthebindingofAsubunitalterstheenzymaticactivityofthecatalyticsubunit,eveniftheBsubunitisabsent.PP2AcanmodulatetheactivityofphosphorylaseBkinasecaseinkinase2,mitogen-stimulatedS6kinase,andMAP-2kinase.CandephosphorylateSV40largeTantigenandp53.DephosphorylatesSV40largeTantigen,preferentiallyonserineresidues120,123,677,andperhaps679.TheCsubunitwasmostactive,followedbytheACform,whichwasmoreactivethantheABCform,andactivityofallthreeformswasstronglystimulatedbymanganese,andtoalesserextentbymagnesium.DephosphorylationbytheACform,butnotCorABCformisinhibitedbysmallTantigen.
ProductReferences
1)MumbyM,(2007)Cell.130(1):21-24.(General)
2)XuYetal.,(2006)Cell.127(6):1239-1251.(General)
3)AvdiNJetal.,(2002)JBiolChem.277(43):40687-40696.(General)
2)XuYetal.,(2006)Cell.127(6):1239-1251.(General)
3)AvdiNJetal.,(2002)JBiolChem.277(43):40687-40696.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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