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Adipogen/anti-PON3 (Paraoxonase 3), mAb (5G11)/YIF-LF-MA0273/100 µl
Adipogen/anti-PON3 (Paraoxonase 3), mAb (5G11)/YIF-LF-MA0273/100 µl
商品编号：
YIF-LF-MA0273
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PON3;EC=3.1.8.1;EC=3.1.1.2;EC=3.1.1.81;SerumParaoxonase/Lactonase3 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 5G11 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanHis-PON3proteinpurifiedfromE.coli. |
| Application | WesternBlot(1:2,000) |
| Crossreactivity | Human |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Paraoxonasesareagroupofenzymesinvlovedinthehydrolysisoforganophosphates.Paraoxon,anorganophosphate,isanacetylcholinesteraseinhibitorandtheactivemetaboliteoftheinsecticideparathion.Besidesatoxicologicalrole,clinicalinteresthasfocusedonaprotectiveroleinvasculardisease.Paraoxonase-1(PON1)isacalcium-dependentesterhydrolasethatistightlyassociatedwithapoA-IinHDL.PON1preventstheoxidationofLDL,therebytheformationofatherogenicoxidised-LDL.PolymorphismsofthehumanPON1genearecorrelatedwithcoronaryarterydisease,indicatingageneticassociationbetweenPON1andcoronaryarterydisease.PON1activityislowerinsubjectspronetodevelopmentofatherosclerosissuchasintype1andtype2diabetes,familialhypercholesterolemia,andrenaldisease,indicatingtheinvolvementofPON1inatherosclerosisdevelopment.PON2isaubiquitouslyexpressedintracellularproteinthatcanprotectcellsagainstoxidativedamage.PON3issimilartoPON1inactivitybutdiffersfromitinsubstratespecificity.PON1andPON3areimplicatedinloweringtheriskofdevelopingcoronaryarterydiseaseandatherosclerosis.HumanPON3proteinsharesthe3conservedcysteineresiduesidentifiedinPON1,suggestingtheirimportanceofinvivoactivities.PON1-basedcatalyticscavengerscanbeawaytosafeandeffectiveorganophosphateintoxication.Hasverylimitedarylesteraseandnoparaoxonaseactivitiesbutrapidlyhydrolyzeslactonessuchasstatinprodrugs(e.g.lovastatin).Hydrolyzesaromaticlactonesand5-or6-memberringlactoneswithaliphaticsubstituentsbutnotsimplelactonesorthosewithpolarsubstituents.
ProductReferences
1)RochuDetal.(2007)Toxicology.233(1-3):47-59.(General)
2)MacknessMandMacknessB,(2004)FreeRADIcBiolMed.37(9):1317-1323(General)
3)ReddySTetal.(2001)Arterioscler.Thromb.Vasc.Biol.21(4):542–547(General)
2)MacknessMandMacknessB,(2004)FreeRADIcBiolMed.37(9):1317-1323(General)
3)ReddySTetal.(2001)Arterioscler.Thromb.Vasc.Biol.21(4):542–547(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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