脂肪原/抗PIDD，pAb（AL233）/AG-25B-0015-C050/50µg
商品编号：
AG-25B-0015-C050
品牌：
Adipogen Inc
市场价：
¥4400.00
美元价：
2640.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | p53-induced Protein with a Death Domain; Leucine-rich Repeat and Death Domain-containing Protein; Lrdd |
| Product Type | Polyclonal Antibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Recombinant human PIDD (Death Domain: aa 776-910). |
| Application |
Immunohistochemistry: (paraffin sections) Immunoprecipitation: (1:100) Western Blot: (1:500) |
| Crossreactivity |
Human Mouse |
| Specificity | Recognizes human and the native form of mouse PIDD. Detects bands of ~90kDa (full length protein) and ~50kDa (cleaved protein) by Western blot. |
| Purity Detail | Epitope-affinity purified. |
| Concentration | 1 mg/ml |
| Formulation | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-κ-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.
Product References
- The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress: A. Tinel & J. Tschopp; Science 304, 843 (2004)
- PIDD mediates NF-kB activation in Response to DNA damage: Janssens et al.; Cell 123, 1079 (2005)
- Heat shock induces apoptosis independently of any known initiator caspase-activating complex: R.S. Milleron & S.B. Bratton; J. Biol. Chem. 281, 16991 (2006)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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