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Adipogen/anti-Periostin, mAb (blocking) (OC-20) (preservative free)/AG-20B-6000PF-C100/100 µg
Adipogen/anti-Periostin, mAb (blocking) (OC-20) (preservative free)/AG-20B-6000PF-C100/100 µg
商品编号：
AG-20B-6000PF-C100
品牌：
Adipogen Inc
市场价：
¥7600.00
美元价：
4560.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Osteoblast-specificFactor2;OSF-2;Postn |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | OC-20 |
| Isotype | MouseIgMκ |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | Recombinantfragmentsofhumanperiostin. |
| Application | FunctionalApplication:Blocksinteractionwiththeintegrinsαvβ3andαvβ5.Inhibitsangiogenesisandtumorgrowthandblocksallergen-inducedinflammationinvivoinmice.Itisactiveat2µg/mlinvitroandinjectedat200µg/mouseforinvivostudies. Immunocytochemistry:(5μg/ml) ForWB,IHCorELISAuse:anti-Periostin,mAb(Stiny-1)(AG-20B-0033) |
| Crossreactivity | Human Mouse |
| Specificity | Recognizeshumanandmouseperiostin.DetectstheFAS1-2domainofperiostinatanewbindingsitefortheintegrinsαvβ3andαvβ5. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinL-affinitypurified. |
| Concentration | Lotdependent |
| Formulation | Liquid.In20mMsodiumphosphatebuffer,pH7.6containing150mMsodiumchloride. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Periostinisa90-kDamatricellularproteinthatconsistsofatypicalsignalsequence,followedbyacysteine-richregion,anEMIdomain(protein-proteininteractions),fourtandemfasciclin-likedomainsthatareresponsIBLeforintegrinbinding,andaC-terminalregion.Periostinwasoriginallyisolatedasanosteoblast-specificfactorthatfunctionsasacelladhesionmoleculeforpre-osteoblastsandinosteoblastrecruitment,attachmentandspreADIng.PeriostinisalsoinvolvedinmanyfundamentalBIOLOGicalprocessessuchascellproliferation,cellinvasionandangiogenesis.Periostinexpressionisincreasedbybothtransforminggrowthfactorβ1(TGF-β1)andbonemorphogeneticprotein2(BMP-2).Changesinperiostinexpressionarecommonlydetectedinvariouscancersandpre-cancerousconditions,andperiostinmaybeinvolvedinregulatingcancercellactivitiesthatcontributetotumOrigenesis,cancerprogressionandmetastasis.Periostinhasshowntobeinvolvedinmanyaspectsofallergicinflammation,suchaseosinophilrecruitment,airwayremodeling,developmentofaTh2phenotypeandincreasedexpressionofinflammatorymediators.ItisevaluatedasabioMarkerforbronchialasthmaandairwayinflammation.
ProductReferences
- Identificationofanovelcellbindingsiteofperiostininvolvedintumourgrowth:P.Orecchia,etal.;Eur.J.Cancer47,2221(2011)
- Periostinpromotesfibrosisandpredictsprogressioninpatientswithidiopathicpulmonaryfibrosis:P.K.Naik,etal.;Am.J.Physiol.LungCellMol.Physiol.303,L1046(2012)
- Periostinisrequiredformaximalairwaysinflammationandhyperresponsivenessinmice:J.K.Bentley,etal.;J.AllergyClin.Immunol.134,1433(2014)
- Periostinisanoveltherapeutictargetthatpredictsandregulatesgliomamalignancy:A.M.Mikheev,etal.;NeuroOncol.17,372(2015)
- Periostin:itsroleinasthmaanditspotentialasadiagnosticortherapeutictarget:W.Li,etal.;Resp.Res.16,57(2015)
- Imagingofsecretedextracellularperiostin,animportantmarkerofinvasioninthetumormicroenvironmentinesophagealcancer:P.Heidari,etal.;J.Nucl.Med.56,1246(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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