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Adipogen/anti-PDGF Receptor β (Phospho-Tyr740), pAb/YIF-LF-PA0036/100 µl
Adipogen/anti-PDGF Receptor β (Phospho-Tyr740), pAb/YIF-LF-PA0036/100 µl
商品编号：
YIF-LF-PA0036
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | PolyclonalAntibody |
| Properties | |
| Immunogen/Antigen | Syntheticphospholyratedpeptide(KLHcoupled)correspondingtoresiduessurroundingTyr740ofhumanPDGFReceptorβ. |
| Application | WesternBlot(1:2,000) |
| Crossreactivity | Human Mouse |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Platelet-derivedgrowthfactors(PDGFs)havebeenimplicatedinthecontrolofcellproliferation,survivalandmigration.ThePDGFfamilyofgrowthfactorsconsistsoffivedifferentdisulphide-linkeddimersbuiltupoffourdifferentpolypeptidechainsencodedbyfourdifferentgenes.Thesesisoforms,PDGF-AA,PDGF-AB,PDGF-BB,PDGF-CCandPDGF-DD,actviatworeceptortyrosinekinases,PDGFreceptorsαandβ.Thusfar,gene-targetingexperimentshavebeenattemptedtocreateknockoutmicedeficientforPDGFR-αorPDGFR-β.Thosemice,however,diedeitherattheembryonicstageorseveraldaysafterbirth.Platelet-derivedgrowthfactorreceptors,PDGFR-αandPDGFR-β,havefiveextracellularimmunoglobulin-likedomainsandanintracellulartyrosinekinasedomain.UponbindingaPDGF,thereceptorsformhomo-andheterodimers.Dimerizationofthereceptorsjuxtaposestheintracellularpartofthereceptors,whichallowphosphorylationintransbetweenthetworeceptorsinthecomplex.Theseautophosphorylationprovidedockingsitesfordownstreamsignaltransductionmolecules.Morethan10differentSH2–domain-containingmoleculeshavebeenshowntobindtodifferentautophosphorylationsitesinthePDGFα-andβ-receptors.Therearesignaltransductionmoleculeswithenzymaticactivity,suchasPI3-kinase,PLC-γ,Src,SHP-2,GAP,aswellasadaptormoleculessuchasGrb2,Shc,Nck,Grb7andCrk,andStats.Eachofthedifferentpartnersrecruitedbytheactivatedreceptorinitiatesdifferentsignalingpathways,makingpossIBLeagreatvarietyofcellularresponse.ReceptorthatbindsspecificallytoPDGFBandPDGFDandhasatyrosine-proteinkinaseactivity.PhosphorylatesTyrresiduesattheC-terminusofPTPN11creatingabindingsitefortheSH2domainofGRB2.
ProductReferences
1)Heldin,CH.etal.(1998)Biochim.Biophys.Acta,1378(1)|F79-F113.(General)
2)Claesson-Welsh,L.(1994)J.Biol.Chem.269(51)|32023-32026.(General)
3)Soriano,P.(1997)Development,124,2691-2700.(General)
4)Soriano,P.(1994)GenesDev.8,1888-1896.(General)
2)Claesson-Welsh,L.(1994)J.Biol.Chem.269(51)|32023-32026.(General)
3)Soriano,P.(1997)Development,124,2691-2700.(General)
4)Soriano,P.(1994)GenesDev.8,1888-1896.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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