当前位置：
首页
>
产品中心 >
Functional_antibody >
Adipogen/anti-PARP-10 [ARTD10] (human), mAb (5H11)/AG-20T-0004-L001/1 ml
![Adipogen/anti-PARP-10 [ARTD10] (human), mAb (5H11)/AG-20T-0004-L001/1 ml](https://www.ebiomall.cn/images/adipogen/ag-20t-0004-if.png)
Adipogen/anti-PARP-10 [ARTD10] (human), mAb (5H11)/AG-20T-0004-L001/1 ml
商品编号：
AG-20T-0004-L001
品牌：
Adipogen Inc
市场价：
¥5800.00
美元价：
3480.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ADP-ribosyltransferaseDiphtheriaToxin-like10;Poly(ADP-ribose)Polymerase-10 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 5H11 |
| Isotype | RatIgG1 |
| Immunogen/Antigen | RecombinanthumanPARP-10[ARTD10](aa1-907)fusedtoaGST-tag. |
| Application | Immunocytochemistry:(1:50-1:200) Immunoprecipitation:(1:10) WesternBlot:(1:50) Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Human |
| Specificity | RecognizeshumanPARP-10[ARTD10]withanepitopebetweenaa256-407,containingtheglycinerich(G-rich)region. |
| EndotoxinContent | |
| Formulation | Liquid.CellculturesupernatantcontainingRPMI,10%FCSand0.05%sodiumazide. |
| OtherProductData | http://www.uniprot.org/uniprot/Q53GL7 |
| AccessionNumber | Q53GL7 |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
PARP-10 [ARTD10]isamono-ADP-ribosyltransferaseandwasinitiallyidentifiedasaninteractionpartneroftheproto-oncoproteinMyc.PARP-10 possessesubiquitin-interactionmotifs,whichareimportanttoinhibittheactivationofNF-κBanddownstreamtargetgenesinresponsetointerleukin-1β[IL-1β]andtumornecrosisfactor-α[TNF-α].PARP-10mono(ADP-ribosyl)ates(MARylates)NEMO(NF-κBessentialmodulator),whichresultsinreducedNEMOpolyubiquitylationandthusdecreasedNF-κBsignaling.OverexpressionofPARP-10wasshowntoleadtoapoptosis.PARP-10knockdownleadstoincreasedcellsurvival.AdditionalsubstratesofPARP-10,suchasGSK-3βwereidentifiedandPARP-10-mediatedmono(ADP-ribosyl)ation(MARylation)wasshowntobeinvolvedinregulatingmultipleprocesses,includingWntsignaling.
ProductReferences
- PARP-10,anovelMyc-interactingproteinwithpoly(ADP-ribose)polymeraseactivity,inhibitstransformation:M.Yu,etal.;Oncogene24,1982(2005)
- Dynamicsubcellularlocalizationofthemono-ADP-ribosyltransferaseARTD10andinteractionwiththeubiquitinreceptorp62:H.Kleine,etal.;CellCommun.Signal.10,28(2012)
- RegulationofNF-κBsignallingbythemono-ADP-ribosyltransferaseARTD10:P.Verheugd,etal.;Nat.Commun.4,1683(2013)
- ARTD10substrateidentificationonproteinmicroarrays:regulationofGSK3βbymono-ADP-ribosylation:K.L.Feijs,etal.;CellCommun.Signal.11,1(2013)
- Macrodomain-containingproteins:regulatingnewintracellularfunctionsofmono(ADP-ribosyl)ation: K.L.Feijs,etal.;Nat.Rev.Mol.CellBiol.13,443(2013)
- Caspase-dependentcleavageofthemono-ADP-ribosyltransferaseARTD10interfereswithitspro-apoptoticfunction:N.Herzog,etal.;FEBSJ.280,1330(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
