当前位置：
首页
>
产品中心 >
Functional_antibody >
Adipogen/anti-PARP-1 [ARTD1] (human), pAb/AG-25T-0002-R100/100 µl
![Adipogen/anti-PARP-1 [ARTD1] (human), pAb/AG-25T-0002-R100/100 µl](https://www.ebiomall.cn/images/adipogen/adipogen_logo_bw_2.png){kind=logo}
Adipogen/anti-PARP-1 [ARTD1] (human), pAb/AG-25T-0002-R100/100 µl
商品编号：
AG-25T-0002-R100
品牌：
Adipogen Inc
市场价：
¥4400.00
美元价：
2640.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Poly(ADP-ribose)Polymerase1;ADP-ribosyltransferaseDiphtheriaToxin-like1;NAD(+)ADP-ribosyltransferase1 |
| ProductType | PolyclonalAntibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | RecombinanthumanPARP-1[ARTD1](aa215-525). |
| Application | Immunocytochemistry:1:500-1:1"000 Immunohistochemistry:1:500-1:1"000 Immunoprecipitation:2μlper100μgnuclearextract WesternBlot:1:2"000-1:5"000 Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Human Monkey Mouse |
| Specificity | RecognizeshumanPARP-1.Cross-reactsweaklywithmouseandmonkeyPARP-1. |
| Formulation | Liquid.Contains0.1%sodiumazide. |
| OtherProductData | UniProtIDP09874:PARP-1(human) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
PARP-1(ARTD1)isinvolvedinthebaseexcisionrepair(BER)pathway,bycatalyzingthepoly(ADP-ribosyl)ationofalimitednumberofacceptorproteinsinvolvedinchromatinarchitectureandinDNAmetabolism.ThismodificationfollowsDNAdamagesandappearsasanobligatorystepinadetection/signalingpathwayleADIngtothereparationofDNAstrandbreaks.PARP-1positivelyregulatesthetranscriptionofMTUS1andnegativelyregulatesthetranscriptionofMTUS2/TIP150.ItformsacomplexwithEEF1A1andTXKthatactsasaT-helper1(Th1)cell-specifictranscriptionfactorandbindsthepromoterofIFN-γtodirectlyregulateitstranscription,andisthusinvolvedimportantlyinTh1cytokineproduction.
ProductReferences
- Noncleavablepoly(ADP-ribose)polymerase-1regulatestheinflammationresponseinmice:V.Petrilli,etal.;J.Clin.Invest.114,1072(2004)
- AcetylationofPARP-1byp300/CBPregulatescoactivationofNF-kappaB-dependenttranscription:P.O.Hassa,etal.;J.Biol.Chem.280,40450(2005)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
