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Adipogen/anti-PAG [Cbp], pAb (IG-452)/AG-25T-0108-C100/100 µg
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Adipogen/anti-PAG [Cbp], pAb (IG-452)/AG-25T-0108-C100/100 µg
商品编号：
AG-25T-0108-C100
品牌：
Adipogen Inc
市场价：
¥9800.00
美元价：
5880.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PhosphoproteinAssociatedwithGlycosphingolipid-enrichedMicrodomains1;Csk-bindingProtein |
| ProductType | PolyclonalAntibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | Syntheticpeptidecorrespondingtoaa412-424oftheN-terminalratPAGincludinganadditionalN-terminalCysresidue. |
| Application | Immunocytochemistry:(1:50) Immunoprecipitation:(5μg/sample) WesternBlot:(1:1"000) Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Human Mouse Rat |
| Specificity | Recognizesmouse,ratandhumanPAG/Cbp. |
| Purity | Antigenaffinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining0.02%sodiumazide. |
| OtherProductData | PositiveControlforWesternBlot:Use1.5x106totalsplenocytesperlane. |
| AccessionNumber | UniProtIDQ9JM80:PAG/Cbp(rat) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
PAG[Cbp]isaubiquitouslyexpressedtransmembraneadapterprotein.Dependingonitsphosphorylationstatus,itappearsasdiffuseband(s)of80-90kDabySDS-PAGE,withphosphorylationleADIngtoashifttowardsahigherapparentmolecularmass.TyrosinephosphorylatedPAGrecruitsCsktothemembraneandnegativelyregulatesSrcfamilykinasesviaCsk-mediatedphosphorylation.UponTcellreceptorengagement,PAGbecomesdephosphorylated,therebydisplacingCskfromthemembraneandenablingtheactivationoftheSrckinasesFynandLck.PAGnegativelyregulatesTCR(Tcellantigenreceptor)-mediatedsignalinginTcellsandFCER1(highaffinityimmunoglobulinepsilonreceptor)-mediatedsignalinginmastcells.ItpromotesCSKactivationandrecruitmenttolipidrafts,whichresultsinLCKinhibition.Itinhibitsimmunologicalsynapseformationbypreventingdynamicarrangementoflipidraftproteinsandmaybeinvolvedincelladhesionsignaling.
ProductReferences
- FynregulatesthedurationofTCRengagementneededforcommitmenttoeffectorfunction:A.Filby,etal.;J.Immunol.179,4635(2007)
- PhosphoproteinAssociatedwithGlycosphingolipid-EnrichedMicrodomainsDifferentiallyModulatesSrcKinaseActivityinBrainMaturation:S.Lindquist,etal.;PLoSONE6,e23978(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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