Adipogen/anti-p53 (Phospho-Ser6), pAb/YIF-LF-PA0201/100 µl
商品编号：
YIF-LF-PA0201
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Phospho-P53;Phospho-TP53;Phospho-AntigenNY-CO-13;Phospho-Phosphoproteinp53;Phospho-TumorSuppressorp53;Phospho-CellularTumorAntigenp53 |
| ProductType | PolyclonalAntibody |
| Properties | |
| Immunogen/Antigen | Syntheticphospho-peptide. |
| Application | WesternBlot(1:1,000) ELISA&Immunoprecipitationnottested. |
| Crossreactivity | Human |
| PurityDetail | Affinitypurification. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
p53isatranscriptionfactorthatregulatesthecellcycleandhencefunctionsasatumorsuppressor.p53hasbeendescribedas"theguardianofthegenome",referringtoitsroleinconservingstabilitybypreventinggenomemutation.p53hasmanyanti-cancermechanisms:activatingDNArepairproteinswhenDNAhassustaineddamage,holdingthecellcycleattheG1/SregulationpointonDNAdamagerecognition,initiatingapoptosisiftheDNAdamageprovestobeirrepairable.Humanp53is393aminoacidslongandhasthreedomains:N-terminaltranscription-activationdomain(TAD),whichactivatestranscriptionfactors.2)centralDNA-bindingcoredomain(DBD)3)C-terminalhomo-oligomerisationdomain(OD);tetramerizationgreatlyincreasestheactivityofp53invivo.Mutationsthatdeactivatep53incancerusuallyoccurintheDBDandmostofthesemutationsdestroytheabilityoftheproteintobindtoitstargetDNAsequences.Theactivityofp53isregulatedatdifferentlevelsandincludescontrolbymulti-sitephosphorylation.p53isphosphorylated(Ser6andSer9)bycaseinkinase1δandcaseinkinase1εbothinvitroandinvivo.Actsasatumorsuppressorinmanytumortypes;inducesgrowtharrestorapoptosisdependingonthephysiologicalcircumstancesandcelltype.Involvedincellcycleregulationasatrans-activatorthatactstonegativelyregulatecelldivisionbycontrollingasetofgenesrequiredforthisprocess.Oneoftheactivatedgenesisaninhibitorofcyclin-dependentkinases.CancerinductionseemstobemediatedeitherbystimulationofBAXandFASantigenexpression,orbyrepressionofBcl-2expression.ImplicatedinNotchsignalingcross-over.
ProductReferences
1)McCormickF,(2001)NatRevCancer1(2):130-41.(General)
2)VogelsteinBetal.,(2000)Nature408(6810):307-10.(General)
3)BlagosklonnyMV,(2002)IntJCancer98(2):161-6.(General)
4)KnippschildUetal.,(1997)Oncogene15(14):1727-36.(General)
2)VogelsteinBetal.,(2000)Nature408(6810):307-10.(General)
3)BlagosklonnyMV,(2002)IntJCancer98(2):161-6.(General)
4)KnippschildUetal.,(1997)Oncogene15(14):1727-36.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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