Adipogen/anti-p-H2AX, pAb/YIF-LF-PA0025/100 µl
商品编号：
YIF-LF-PA0025
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | H2AX;H2AFX;H2a/x;HistoneH2AX;HistoneH2A.X |
| ProductType | PolyclonalAntibody |
| Properties | |
| Immunogen/Antigen | Syntheticpeptide. |
| Application | WesternBlot(1:5,000) |
| Crossreactivity | Human |
| PurityDetail | Affinitypurification. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
HistoneH2Aisoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.Thenucleosomeinwhichan147base-pairsofDNAarewrapped1.7timesaroundacentralcoreofeighthistoneproteinmoleculesformsthebasicbuildingblockofchromatin.HistoneoctamerconsistsoftwocopieseachofH2A,H2B,H3,andH4histones.HistoneH2AvariantH2AX,acomponentofthenucleosomecorestructurethatcomprises10%–15%oftotalcellularH2A,hasaspecialroleinDNArepair,cellcyclecheckpoints,regulatedgenerecombinationevents,andtumorsuppression.H2AXcanbephosphorylatedonSer1,acetylatedonLys5andubiquitinatedonLys119.ButwhatmakesH2AXuniqueisahighlyconservedserine139residuewhichisrapidlyphosphorylatedupontheexposureofcellstoDNAdamage.H2AXisphosphorylatedbyATRinresponsetoDNAreplicationstress,andprimarilybyATMinresponsetolowlevelsofionizingrADIation.PhosphorylationofH2AXincreasesthelikelihoodofassemblingafunctionalrepaircomplexbyincreasingthelocalconcentrationofrepairfactorsnearthelesion.VarianthistoneH2AwhichreplacesconventionalH2Ainasubsetofnucleosomes.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.Requiredforcheckpoint-mediatedarrestofcellcycleprogressioninresponsetolowdosesofionizingradiationandforefficientrepairofDNAdoublestrandbreaks(DSBs)specificallywhenmodifiedbyC-terminalphosphorylation.
ProductReferences
1)StuckiM,etal.(2005),Cell.123(7):1213-1226.(General)
2)Fernandez-CapetilloO,etal.(2004),DNARepair(Amst).3(8-9):959-967.(General)
3)EmmyP.Rogakou,etal.(1998),JBiolChem.273(10):5858-5868.(General)
2)Fernandez-CapetilloO,etal.(2004),DNARepair(Amst).3(8-9):959-967.(General)
3)EmmyP.Rogakou,etal.(1998),JBiolChem.273(10):5858-5868.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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