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当前位置: 首页 > 产品中心 > Functional_antibody > Adipogen/anti-NS5B (HCV), mAb (blocking) (5B-12B7)/AG-20B-0003-C100/100 µg
商品详细Adipogen/anti-NS5B (HCV), mAb (blocking) (5B-12B7)/AG-20B-0003-C100/100 µg
Adipogen/anti-NS5B (HCV), mAb (blocking) (5B-12B7)/AG-20B-0003-C100/100 µg
Adipogen/anti-NS5B (HCV), mAb (blocking) (5B-12B7)/AG-20B-0003-C100/100 µg
商品编号: AG-20B-0003-C100
品牌: Adipogen Inc
市场价: ¥6600.00
美元价: 3960.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
MoreInformation
ProductDetails
SynonymsNonstructuralProtein5B
ProductTypeMonoclonalAntibody
Properties
Clone5B-12B7
IsotypeMouseIgG2a
Source/HostPurifiedfromconcentratedhybridomatissueculturesupernatant.
Immunogen/AntigenRecombinanthepatitisCvirus(HCV)NS5BRNA-dependentRNApolymerase.
ApplicationImmunocytochemistry:(1:100)
Immunoprecipitation
FunctionalApplication:BlockstheRNA-dependentRNApolymeraseactivityinvitro.
Note:NotsuitableforWesternblot.Useanti-NS5B(HCV)mAb(5B-3B1)(Prod.No.AG-20B-0002).
CrossreactivityHCV
SpecificityRecognizesHCVNS5BfromHCVgenotype1(epitopemappedtoNS5Baa139-392).Doesnotreactwithgenotype2.
Purity≥95%(SDS-PAGE)
PurityDetailProteinG-affinitypurified.
Concentration1mg/ml
FormulationLiquid.InPBScontaining0.02%sodiumazide.
ShippingandHandling
ShippingBLUEICE
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceAfteropening,preparealiquotsandstoreat-20°C.
Avoidfreeze/thawcycles.
Use/StABIlityStableforatleast1yearafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
TheNS3serineprotease,inassociationwithNS4A,isresponsIBLeforthecleavagesoftheHepatitisCvirusproteasecomplexesNS3-NS4A,NS4A-NS4B,NS4B-NS5AandNS5A-NS5B.NS5BisaRNA-dependentRNApolymerasethatplaysanessentialroleinthevirusreplication.HepatitisCvirusproteaseNS3-NS4AcolocalizeswithIPS-1/VISA/MAVS/CardifinthemitochondrialmembraneandhasbeenshowntocleavetheTLR3adapterTRIFandCardiftoeliminatetheantiviralsignalingpathways.NS3-NS4Arepresentsanimportanttargetforanti-HCVdrugs.
ProductReferences
  1. DeterminantsformembraneassociationofthehepatitisCvirusRNA-dependentRNApolymerase:J.Schmidt-Mende,etal.;J.Biol.Chem.276,44052(2001)
  2. FunctionalpropertiesofamonoclonalantibodyinhibitingthehepatitisCvirusRNA-dependentRNApolymerase:D.Moradpour,etal.;J.Biol.Chem.277,593(2002)
  3. Protein-proteininteractionsbetweenhepatitisCvirusnonstructuralproteins:Dimitrova,etal.;J.Virol.77,5401(2003)
  4. InterferenceofhepatitisCvirusRNAreplicationbyshortinterferingRNAs:KapADIa,etal.;PNAS100,2014(2003)
品牌介绍
Adipogen公司由三个子公司组成,分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国,运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发,如癌症、免疫、炎症、代谢疾病(糖尿病、肥胖)、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外,也可提供抗体和蛋白产品,Adipogen拥有自己的化学实验室,致力于开发创新型小分子化合物。