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Adipogen/anti-NS5B (HCV), mAb (blocking) (5B-12B7)/AG-20B-0003-C100/100 µg
Adipogen/anti-NS5B (HCV), mAb (blocking) (5B-12B7)/AG-20B-0003-C100/100 µg
商品编号:
AG-20B-0003-C100
品牌:
Adipogen Inc
市场价:
¥6600.00
美元价:
3960.00
产品分类:
功能性抗体
公司分类:
Functional_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NonstructuralProtein5B |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 5B-12B7 |
| Isotype | MouseIgG2a |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | RecombinanthepatitisCvirus(HCV)NS5BRNA-dependentRNApolymerase. |
| Application | Immunocytochemistry:(1:100) Immunoprecipitation FunctionalApplication:BlockstheRNA-dependentRNApolymeraseactivityinvitro. Note:NotsuitableforWesternblot.Useanti-NS5B(HCV)mAb(5B-3B1)(Prod.No.AG-20B-0002). |
| Crossreactivity | HCV |
| Specificity | RecognizesHCVNS5BfromHCVgenotype1(epitopemappedtoNS5Baa139-392).Doesnotreactwithgenotype2. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
TheNS3serineprotease,inassociationwithNS4A,isresponsIBLeforthecleavagesoftheHepatitisCvirusproteasecomplexesNS3-NS4A,NS4A-NS4B,NS4B-NS5AandNS5A-NS5B.NS5BisaRNA-dependentRNApolymerasethatplaysanessentialroleinthevirusreplication.HepatitisCvirusproteaseNS3-NS4AcolocalizeswithIPS-1/VISA/MAVS/CardifinthemitochondrialmembraneandhasbeenshowntocleavetheTLR3adapterTRIFandCardiftoeliminatetheantiviralsignalingpathways.NS3-NS4Arepresentsanimportanttargetforanti-HCVdrugs.
ProductReferences
- DeterminantsformembraneassociationofthehepatitisCvirusRNA-dependentRNApolymerase:J.Schmidt-Mende,etal.;J.Biol.Chem.276,44052(2001)
- FunctionalpropertiesofamonoclonalantibodyinhibitingthehepatitisCvirusRNA-dependentRNApolymerase:D.Moradpour,etal.;J.Biol.Chem.277,593(2002)
- Protein-proteininteractionsbetweenhepatitisCvirusnonstructuralproteins:Dimitrova,etal.;J.Virol.77,5401(2003)
- InterferenceofhepatitisCvirusRNAreplicationbyshortinterferingRNAs:KapADIa,etal.;PNAS100,2014(2003)
品牌介绍
Adipogen公司由三个子公司组成,分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国,运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发,如癌症、免疫、炎症、代谢疾病(糖尿病、肥胖)、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外,也可提供抗体和蛋白产品,Adipogen拥有自己的化学实验室,致力于开发创新型小分子化合物。
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