Adipogen/anti-NS3 (HCV), mAb (1B6)/AG-20B-0001-C100/100 µg
商品编号：
AG-20B-0001-C100
品牌：
Adipogen Inc
市场价：
¥6600.00
美元价：
3960.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NonstructuralProtein3 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 1B6 |
| Isotype | MouseIgG1 |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | RecombinanthepatitisCvirus(HCV)NS3serineproteasedomain. |
| Application | Immunocytochemistry:(paraformaldehydefixation)(1:50) WesternBlot:(1:500) |
| Crossreactivity | HCV |
| Specificity | RecognizesHCVNS3(genotype1aand1b)(epitopemappedtoNS3aa160-193),recognizesNS3aloneortheNS3-4Acomplex.Doesnotcross-reactwithHCVNS3(genotype2a). |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
TheNS3serineprotease,inassociationwithNS4A,isresponsIBLeforthecleavagesoftheHepatitisCvirusproteasecomplexesNS3-NS4A,NS4A-NS4B,NS4B-NS5AandNS5A-NS5B.NS5BisaRNA-dependentRNApolymerasethatplaysanessentialroleinthevirusreplication.HepatitisCvirusproteaseNS3-NS4AcolocalizeswithIPS-1/VISA/MAVS/CardifinthemitochondrialmembraneandhasbeenshowntocleavetheTLR3adapterTRIFandCardiftoeliminatetheantiviralsignalingpathways.NS3-NS4Arepresentsanimportanttargetforanti-HCVdrugs.
ProductReferences
- Subcellularlocalization,stability,andtrans-cleavagecompetenceofthehepatitisCvirusNS3-NS4Acomplexexpressedintetracycline-regulatedcelllines:B.Wolk,etal.;J.Virol.74,2293(2000)
- Protein-proteininteractionsbetweenhepatitisCvirusnonstructuralproteins:Dimitrova,etal.;J.Virol.77,5401(2003)
- IdentificationofthehepatitisCvirusRNAreplicationcomplexinHuh-7cellsharboringsubgenomicreplicons:R.Gosert,etal.;J.Virol.77,5487(2003)
- Insertionofgreenfluorescentproteinintononstructuralprotein5AallowsdirectvisualizationoffunctionalhepatitisCvirusreplicationcomplexes:D.Moradpour,etal.;J.Virol.78,7400(2004)
- CardifisanadaptorproteinintheRIG-IantiviralpathwayandistargetedbyhepatitisCvirus:E.Meylan,etal.;Nature437,1167(2005)
- HepatitisCvirusRNAreplicationisregulatedbyhostgeranylgeranylationandfattyacids:S.B.KapADIaandF.V.Chisari;PNAS102,2561(2005)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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