脂肪原/抗-NLRP3/NALP3，单克隆抗体（Cryo-2）/AG-20B-0014-C100/100µg
商品编号：
AG-20B-0014-C100
品牌：
Adipogen Inc
市场价：
¥8000.00
美元价：
4800.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NACHT-,LRR-andPYD-containingProtein3;NLRP3;Cryopyrin;ColdAutoinflammatorySyndrome1Protein |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | Cryo-2 |
| Isotype | MouseIgG2b |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | RecombinantmouseNLRP3/NALP3(pyrindomain/aa1-93). |
| Application | WesternBlot(seeonlineprotocol):(1μg/ml) Immunocytochemistry:(seeJ.Virol.85,13019(2011)andNat.Immunol.13,255(2012)) Immunoprecipitation:(inRIPAbuffer,seeMol.Cell49,331(2012)) Immunohistochemistry:(1:200,foraprotocolseeNature493,67(2012)) ChIPassay:2µg/DNAof10E6cells(seeNat.Immunol.16,859(2015)) |
| Crossreactivity | Human Mouse |
| Specificity | RecognizesmouseandhumanNLRP3/NALP3. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| Protocols |  DownloadPDF |
| MSDS | DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Theinflammasomeisamultiproteincomplexthatmediatestheactivationofcaspase-1,whichpromotes,amongstothers,thesecretionoftheproinflammatorycytokinesinterleukin(IL)-1βandIL-18.MembersoftheNod-likereceptorfamily,includingNLRP3/NALP3,arecriticalcomponentsoftheinflammasomethatlinkdanger-signalstocaspase-1activation.DefectsinNLRP3arethecauseoffamilialcoldautoinflammatorysyndrometype1(FCAS1),Muckle-Wellssyndrome(MWS)andofchronicinfantileneurologiccutaneousandarticularsyndrome(CINCA).
ProductReferences
- Thioredoxin-interactingproteinlinksoxidativestresstoinflammasomeactivation:R.Zhou,etal.;NatureImmunology11,136(2010)
- TheNLRP3inflammasomepromotesrenalinflammationandcontributestoCKD:A.Vilaysane,etal.;J.Am.Soc.Nephrol.21,1732(2010)
- AroleformitochondriainNLRP3inflammasomeactivation:R.Zhou,etal.;Nature469,221(2011)
- DifferentialexpressionofNLRP3amonghematopoieticcells:G.Guarda,etal.;J.Immunol.186,2529(2011)
- MechanismofImpairedNLRP3InflammasomePrimingbyMonophosphorylLipidA:C.A.Embry,etal.;Sci.Signal.4,ra28(2011)
- MeaslesVirusVProteinInhibitsNLRP3Inflammasome-MediatedInterleukin-1Secretion:N.Komune,etal.;J.Virol.85,13019(2011)
- NovelroleofPKRininflammasomeactivationandHMGB1release:B.Lu,etal.;Nature488,670(2012)
- DeubiquitinationofNLRP3byBRCC3CriticallyRegulatesInflammasomeActivity:B.F.Py,etal.;Mol.Cell49,331(2012)
- NLRP3isactivatedinAlzheimer"sdiseaseandcontributestopathologyinAPP/PS1mice:M.T.Heneka,etal.;Nature493,67(2012)
- ActivationofautophagybyinflammatorysignalslimitsIL-1bproductionbytargetingubiquitinatedinflammasomesfordestruction:C.-S.Shi,etal.;Nat.Immunol.13,255(2012)
- Inflammasome-independentNLRP3augmentsTGF-βsignalinginkidneyepithelium:W.Wang,etal.;J.Immunol.190,1239(2013)
- Omega-3FattyAcidsPreventInflammationandMetabolicDisorderthroughInhibitionofNLRP3InflammasomeActivation:Y.Yan,etal.;Immunity38,1154(2013)
- LRRFIP2negativelyregulatesNLRP3inflammasomeactivationinmacrophagesbypromotingFlightless-I-mediatedcaspase-1inhibition:J.Jin,etal.;Nat.Commun.4,2075(2013)
- ProapoptoticChemotherapeuticDrugsInduceNoncanonicalProcessingandReleaseofIL-1βviaCaspase-8inDendriticCells:C.Antonopoulus,etal.J.Immunol.191,4789(2013)
- ConstitutivelyactivatedNLRP3inflammasomecausesinflammationandabnormalskeletaldevelopmentinmice:S.L.Bonar,etal.;PLoSOne7,e35979(2012)
- FADDandcaspase-8mediateprimingandactivationofthecanonicalandnoncanonicalNlrp3inflammasomes:P.Gurung,etal.;J.Immunol.192,1835(2014)
- XIAPRestrictsTNF-andRIP3-DependentCellDeathandInflammasomeActivation:M.Yabal,etal.;CellRep.7,1796(2014)
- TheadaptorASChasextracellularand"prionoid"activitiesthatpropagateinflammation:B.S.Franklin,etal.;Nat.Immunol.15,727(2014)
- TheNLRP3inflammasomeisreleasedasaparticulatedangersignalthatamplifiestheinflammatoryresponse:A.Baroja-Mazo,etal.;Nat.Immunol.15,738(2014)
- TowardachemicalMarkerforinflammatorydisease:afluorescentprobeformembrane-localizedthioredoxin:M.H.Lee,etal.;JACS136,8430(2014)
- ProstaglandinE2inhibitsNLRP3inflammasomeactivationthroughEP4receptorandintracellularcyclicAMPinhumanmacrophages:M.Sokolowska,etal.;J.Immunol.194,5472(2015)
- ThereceptorNLRP3isatranscriptionalregulatorofTH2differentiation:M.Bruchard,etal.;Nat.Immunol.16,859(2015)
- NLRP3InflammasomeIsExpressedandFunctionalinMouseBrainMicrogliabutNotinAstrocytes:A.Gustin,etal.;PLosOne10,e0130624(2015)
- Nlrp6promotesrecoveryafterperipheralnerveinjuryindependentlyofinflammasomes:E.Ydens,etal.;J.Neuroinfl.12,143(2015)
- Humanmonocytesengageanalternativeinflammasomepathway:M.M.Gaidt,etal.;Immunity44,833(2016)
- TheNLRP3inflammasomeandbruton"styrosinekinaseinplateletsco-regulateplateletactivation,aggregation,andinvitrothrombusformation:P.Murthy,etal.;BBRC483,230(2017)
- AnInvestigationofInflammatoryandMetabolicBlood-BasedBiomarkersofCognitiveDecline:H.Wolfe;ThesisUniv.Dublin,TrinityCollege,Dep.ofPhysiol.(2018)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
