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Adipogen/anti-NLRC3 (mouse), mAb (Eowyn-1)/AG-20B-0067-C100/100 µg
Adipogen/anti-NLRC3 (mouse), mAb (Eowyn-1)/AG-20B-0067-C100/100 µg
商品编号：
AG-20B-0067-C100
品牌：
Adipogen Inc
市场价：
¥8000.00
美元价：
4800.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NOD3;Nucleotide-bindingOligomerizationProtein3;CARD15-likeProtein;CaterpillerProtein16.2;CLR16.2 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | Eowyn-1 |
| Isotype | MouseIgG1 |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | RecombinantmouseNLRC3(carddomain). |
| Application | WesternBlot:(1μg/ml) |
| Crossreactivity | Mouse |
| Specificity | DetectsoverexpressedmouseNLRC3.DoestnotdetecthumanNLRC3.AlthoughNLRC3(mouse),mAb(Eowyn-1)isstrongandspecific(seefigure),theendogenousproteinhasnotbeendetectedyetwiththisantibody(usingNLRC3KOversusWTimmunecells).NLRC3proteinisprobablyexpressedatverylowlevelsoritstranslation/stABIlityistriggeredbystimulistilltobediscovered. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/Stability | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Thenovelnucleotideoligomerizationdomain(NOD)-likereceptor(NLR)withacaspaseactivationandrecruitmentdomain(CARD)3(NLRC3)proteinbelongstotheNLRfamilyofcytosolicpathogenrecognitionreceptors.NLRC3hasthecharacteristicNODandleucine-richrepeatconfigurationwithalesswelldefinedCARD.NLRC3isexpressedinTlymphocytesandmaybeinvolvedinsuppressionofTcellactivation.NLRC3isacytoplasmicproteinthatnegativelyregulatespro-IL-1βmaturationandinhibitstoll-likereceptor(TLR)-dependentactivationofthetranscriptionfactorNF-κB.NLRC3interactswiththeTLRsignalingadaptorTRAF6toattenuateLys63(K63)-linkedubiquitinationofTRAF6andactivationofNF-κB.NLRC3alsoreducesSTING-dependentinnateimmuneactivationinresponsetocytosolicDNA,cyclicdi-GMP(c-di-GMP)andDNAviruses.NLRC3associatedwithbothSTINGandTBK1,impedesSTING-TBK1interactionanddownstreamtypeIinterferonproduction.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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