Adipogen/anti-NFATc1, pAb (IG-205)/AG-25T-0110-C050/50 µg
商品编号：
AG-25T-0110-C050
品牌：
Adipogen Inc
市场价：
¥7500.00
美元价：
4500.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NuclearFactorofActivatedTCells;Cytoplasmic1;NFATTranscriptionComplexCytosolicComponent;NF-ATc1 |
| ProductType | PolyclonalAntibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | RecombinantN-terminalhumanNFATc1fragmentfusedtoaGST-tag. |
| Application | ChIP:(1:200) Bandshiftassay:CompeteswithprobeforNFATbinding. Immunocytochemistry: Immunohistochemistry: Immunoprecipitation:(1:200) WesternBlot:(1:500-1:1000) Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Human |
| Specificity | RecognizesallknownhumanNFATc1isoforms. |
| Purity | Antigenaffinitypurified. |
| Concentration | 500μg/ml |
| Formulation | Liquid.InPBScontaining1mg/mlBSAand0.02%sodiumazide. |
| AccessionNumber | UniProtIDO95644:NFATc1 |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
NFATc1playsaroleintheinducIBLeexpressionofcytokinegenesinTcells,especiallyintheinductionoftheIL-2orIL-4genetranscription.Itcontrolsgeneexpressioninembryoniccardiaccells.RegulatesnotonlytheactivationandproliferationbutalsothedifferentiationandprogrammeddeathofT-lymphocytesaswellaslymphoidandnon-lymphoidcells.
ProductReferences
- Pim-1kinaseenhancesNFATcactivityandneuroendocrinefunctionsinPC12cells:M. Glazova,etal.;Mol.BrainRes.138,116(2005)
- SpecificandredundantrolesforNFATtranscriptionfactorsintheexpressionofmastcell-derivedcytokines:M.Klein,etal.;J.Immunol.177,6667(2006)
- EpigeneticchangesandsuppressionofthenuclearfactorofactivatedTcell1(NFATC1)promoterinhumanlymphomaswithdefectsinimmunoreceptorsignaling:A.Akimzhanov,etal.;Am.J.Pathol.172,215(2008)
- CyclicAMP-inducedChromatinChangesSupporttheNFATc-mediatedRecruitmentofGATA-3totheInterleukin5Promoter:S.Klein-Hessling,etal.;J.Biol.Chem.283,31030(2008)
- Stimulationofinterleukin-13expressionbyhumanT-cellleukemiavirustype1oncoproteinTaxviaaduallyactivepromoterelementresponsivetoNF-κBandNFAT:K.Silbermann,etal.;J.Gen.Virol.89,2788(2008)
- SumoylationoftheTranscriptionFactorNFATc1LeadstoItsSubnuclearRelocalizationandInterleukin-2RepressionbyHistoneDeacetylase:A.Nayak,etal.;J.Biol.Chem.284,10935(2009)
- NFATc1affectsmousesplenicBcellfunctionbycontrollingthecalcineurin-NFATsignalingnetwork:S.Bhattacharyya,etal.;J.Exp.Med.208,823(2011)
- NFATc1inductioninperipheralTandBlymphocytes:M.Hock,etal.;J.Immunol.190,2345(2013)
- AnalternativeNFAT-activationpathwaymediatedbyIL-7iscriticalforearlythymocytedevelopment:A.K.Patra,etal.;Nat.Immunol.14,127(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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