Adipogen/anti-NF-κB (p65), pAb/AG-25T-0004-R100/100 µl
商品编号：
AG-25T-0004-R100
品牌：
Adipogen Inc
市场价：
¥4200.00
美元价：
2520.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NuclearFactorNF-κBp65Subunit;TranscriptionFactorp65;RELA |
| ProductType | PolyclonalAntibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | RecombinanthumanNF-κB(p65subunit). |
| Application | Immunocytochemistry:1:250-1:300 Immunoprecipitation:2μg WesternBlot:1:2"000-1:5"000 Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Human Mouse |
| Specificity | RecognizeshumanandmouseNF-κB(p65subunit). |
| Formulation | Liquid.Contains0.1%sodiumazide. |
| OtherProductData | UniProtIDQ04206:NF-κB(human)(p65subunit) |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
NF-κBisapleiotropictranscriptionfactorpresentinalmostallcelltypesandistheendpointofaseriesofsignaltransductioneventsthatareinitiatedbyavastarrayofstimulirelatedtomanyBIOLOGicalprocessessuchasinflammation,immunity,differentiation,cellgrowth,tumOrigenesisandapoptosis.NF-κBisahomo-orheterodimericcomplexformedbytheRel-likedomain-containingproteinsRELA/p65,RELB,NFKB1/p105,NFKB1/p50,RELandNFKB2/p52.Theheterodimericp65-p50complexisthemostabundantcomplex.Thedimersbindatκ-BsitesintheDNAoftheirtargetgenesandtheindividualdimershavedistinctpreferencesfordifferentκBsitesthattheycanbindwithdistinguishableaffinityandspecificity.Differentdimercombinationsactastranscriptionalactivatorsorrepressors,respectively.NF-κBcomplexesareheldinthecytoplasminaninactivestatecomplexedwithmembersoftheNF-κBinhibitor(I-κB)family.Inaconventionalactivationpathway,I-κBisphosphorylatedbyI-κBkinases(IKKs)inresponsetodifferentactivators,subsequentlydegradedthusliberatingtheactiveNF-κBcomplexwhichtranslocatestothenucleus.NF-κBheterodimericp65-p50andp65-c-Relcomplexesaretranscriptionalactivators.TheNF-κBp65-p65complexappearstobeinvolvedininvasin-mediatedactivationofIL-8expression.p65showsaweakDNA-bindingsitewhichcouldcontributedirectlytoDNAbindingintheNF-κBcomplex.
ProductReferences
- Transcriptionalcoactivationofnuclearfactor-kappaB-dependentgeneexpressionbyp300isregulatedbypoly(ADP)-ribosepolymerase-1:P.O.Hassa,etal.;J.Biol.Chem.278,45145(2003)
- AcetylationofPARP-1byp300/CBPregulatescoactivationofNF-kappaB-dependenttranscription:P.O.Hassa,etal.;J.Biol.Chem.280,40450(2005)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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