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Adipogen/anti-NFκB p105/50, mAb (13A2F)/YIF-LF-MA0236/100 µl
Adipogen/anti-NFκB p105/50, mAb (13A2F)/YIF-LF-MA0236/100 µl
商品编号：
YIF-LF-MA0236
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NFKB1;p105;p50 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 13A2F |
| Isotype | MouseIgG2bκ |
| Immunogen/Antigen | RecombinanthumanNFκB(p50)proteinpurifiedfromE.coli. |
| Application | ELISA WesternBlot(1:2,000) |
| Crossreactivity | Human Mouse Rat |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
NF-κB(NuclearFactorκB)isanucleartranscriptionfactorfoundinallcelltypesandisinvolvedincellularresponsestostimulisuchasstress,cytokines,freerADIcals,ultravioletirradiation,andbacterialorviralantigens.NF-κBplaysakeyroleinregulatingtheimmuneresponsetoinfection.Consistentwiththisrole,incorrectregulationofNF-κBhasbeenlinkedtocancer,inflammatoryandautoimmunediseases,septicshock,viralinfectionandimproperimmunedevelopment.TherearefivemembersintheNF-κBfamily:NF-κB1,NF-κB2,RelA(alsonamedp65),RelB,andc-Rel.ThemostcommonformofNF-κBisthep50/RelAheterodimer,althoughotherformsofNF-κBdimers,suchasp50/p50,p52/p52,p52/RelA,p50/c-Rel,c-Rel/c-Rel,p52/RelB,andp50/RelB,havealsobeenidentifiedinsometypesofcells.TheprimaryroleofNF-κBistomaintainnormalcellularfunctionsthatrangefromcell-to-cellcommunicationtocellmotility,cellcycleprogression,andcelllineagedevelopment.TheactivityofNF-κBistightlyregulatedbyinteractionwithinhibitoryIκBproteins.NF-κ-BisapleiotropictranscriptionfactorwhichispresentinalmostallcelltypesandisinvolvedinmanyBIOLOGicalprocessedsuchasinflammation,immunity,differentiation,cellgrowth,tumOrigenesisandapoptosis.NF-κ-Bisahomo-orheterodimericcomplexformedbytheRel-likedomain-containingproteinsRELA/p65,RELB,NFKB1/p105,NFKB1/p50,RELandNFKB2/p52andtheheterodimericp65-p50complexappearstobemostabundantone.Thedimersbindatκ-BsitesintheDNAoftheirtargetgenesandtheindividualdimershavedistinctpreferencesfordifferentκ-Bsitesthattheycanbindwithdistinguishableaffinityandspecificity.Differentdimercombinationsactastranscriptionalactivatorsorrepressors,respectively.NF-κ-Biscontrolledbyvariousmechanismsofpost-translationalmodificationandsubcellularcompartmentalizationaswellasbyinteractionswithothercofactorsorcorepressors.NF-κ-BcomplexesareheldinthecytoplasminaninactivestatecomplexedwithmembersoftheNF-κ-Binhibitor(I-κ-B)family.Inaconventionalactivationpathway,I-κ-BisphosphorylatedbyI-κ-Bkinases(IKKs)inresponsetodifferentactivators,subsequentlydegradedthusliberatingtheactiveNF-κ-Bcomplexwhichtranslocatestothenucleus.NF-κ-Bheterodimericp65-p50andRelB-p50complexesaretranscriptionalactivators.TheNF-κ-Bp50-p50homodimerisatranscriptionalrepressor,butcanactasatranscriptionalactivatorwhenassociatedwithBCL3.NFKB1appearstohavedualfunctionssuchascytoplasmicretentionofattachedNF-κ-Bproteinsbyp105andgenerationofp50byacotranslationalprocessing.Theproteasome-mediatedprocessensurestheproductionofbothp50andp105andpreservestheirindependentfunction,althoughprocessingofNFKB1/p105alsoappearstooccurpost-translationally.p50bindstotheκ-Bconsensussequence5"-GGRNNYYCC-3",locatedintheenhancerregionofgenesinvolvedinimmuneresponseandacutephasereactions.InacomplexwithMAP3K8,NFKB1/p105repressesMAP3K8-inducedMAPKsignaling;activeMAP3K8isreleasedbyproteasome-dependentdegradationofNFKB1/p105.
ProductReferences
1)CampbellKJ,PerkinsND.CellCycle.2004;vol.3(7):p.869-72.(General)
2)PerkinsND.TrendsCellBiol.2004;vol.14(2):p.64-9.(General)
3)ZanettiM,etal,AnnNYAcadSci.2003;vol.987:p.249-57.(General)
2)PerkinsND.TrendsCellBiol.2004;vol.14(2):p.64-9.(General)
3)ZanettiM,etal,AnnNYAcadSci.2003;vol.987:p.249-57.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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