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Adipogen/anti-Neutrophils (mouse), mAb (blocking) (Nimp-R14) (preservative free)/AG-20B-0043PF-M010/10 mg
Adipogen/anti-Neutrophils (mouse), mAb (blocking) (Nimp-R14) (preservative free)/AG-20B-0043PF-M010/10 mg
商品编号：
AG-20B-0043PF-M010
品牌：
Adipogen Inc
市场价：
¥34000.00
美元价：
20400.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | Nimp-R14 |
| Isotype | RatIgG2b |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | PurifiedmouseBALB/cneutrophils. |
| Label/Conjugates | PreservativeFree |
| Application | FlowCytometry:(1:100) Immunohistochemistry:(1:200;frozensection/paraffinsection) Immunocytochemistry:(1:200) Functional(Blocking):250μg/mouse(Optimalreagenttodepleteneutrophilsinvivo) |
| Crossreactivity | Mouse |
| Specificity | Recognizesmouseneutrophils(surfaceproteinmouseLy-6G)andmayrecognizeLy-6Chighcells(inflammatorymonocytes). |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified. |
| EndotoxinContent | <0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | Lotdependent |
| Formulation | Liquid.InPBScontaining10%glycerol. |
| OtherProductData | 10mgSize:Deliveredas5x2mgvials. Negativecontrol:AG-35B-0011 |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Neutrophilsarekeycomponentsoftheinflammatoryresponseandassuchcontributetothekillingofmicroorganisms.Inaddition,recentevidencesuggeststheirinvolvementinthedevelopmentoftheimmuneresponse.TheNimp-R14mAbdisplaysfeaturesofanoptimalreagentallowingtheselectivedepletionofmouseneutrophilsinvivo.
ProductReferences
- Differentiationantigensonmouseeosinophilsandneutrophilsidentifiedbymonoclonalantibodies:A.Lopez,etal.; Brit.J.Haematol.57,489(1984)
- Schistosomamansoni:evidencethatimmunityinvaccinatedandchronicallyinfectedCBA/Camiceissensitivetotreatmentwithamonoclonalantibodythatdepletescutaneouseffectorcells:D.McLaren,etal.; ParasiteImmunol.9,667(1987)
- Monocytes/macrophagesratherthanPMNareinvolvedinearlycartilagedegradationincationicimmunecomplexarthrititsinmice:P.VanLent,etal.;J.Leukoc.Biol.61,267(1997)
- Adenoviralvector-mediatedoverexpressionofIL-4inthekneejointofmicewithcollagen-inducedarthritispreventscartilagedestruction:E.Lubberts,etal.;J.Immunol.163,4546(1999)
- AnimmunomodulatoryfunctionforneutrophilsduringtheinductionofaCD4+Th2responseinBALB/cmiceinfectedwithLeishmaniamajor:F.Tacchini-Cottier,etal.;J.Immunol.165,628(2000)
- AnewmechanismforIL-5-dependenthelminthcontrol:neutrophilaccumulationandneutrophil-mediatedwormencapsulationinmurinefilariasisareabolishedintheabsenceofIL-5:K.M.Al-Qaoud,etal.;Int.Immunol.12,899(2000)
- Rapidrecruitmentofinflammatorymonocytesisindependentofneutrophilmigration:R.B.Henderson,etal.;Blood102,328(2003)
- ComplementfactorC5amediatesrenalischemia-reperfusioninjuryindependentfromneutrophils:B.deVries,etal.;J.Immunol.170,3883(2003)
- Absenceofcross-reactivitybetweenmurineLy-6CandLy-6G:S.Nagendra,etal.;Cytom.A58,195(2004)
- ActivationofToll-LikeReceptor(TLR)2,TLR4,andTLR9intheMammalianCorneaInducesMyD88-DependentCornealInflammation:A.C.Johnson,etal.; Invest.Ophthalmol.Vis.Sci.46,589(2005)
- NeutrophilscontributetodevelopmentofaprotectiveimmuneresponseduringonsetofinfectionwithLeishmaniadonovani:E.McFarlane,etal.;Infect.Immun. 76, 532(2008)
- InnateImmune-induceddepletionofbonemarrowneutrophilsaggravatessystemicbacterialinfections:A.Navarini,etal.;PNAS106,7107(2009)
- AnalysisofinnatedefencesagainstPlasmodiumfalciparuminimmunodeficientmice: ALudovic,etal.;MalariaJ.9,197(2010)
- RoleofNeutrophilsintheEarlyShapingoftheLeishmaniaMajorSpecificImmuneResponseinExperimentalMurineCutaneousLeishmaniasis:M.Charmoy,etal.;NeutrophilsinInfectiousDiseases1,49(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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