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Adipogen/anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative-free)/AG-27B-0018PF-C500/500 µg
Adipogen/anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative-free)/AG-27B-0018PF-C500/500 µg
商品编号：
AG-27B-0018PF-C500
品牌：
Adipogen Inc
市场价：
¥19000.00
美元价：
11400.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NTN1 |
| ProductType | RecombinantAntibody |
| Properties | |
| Clone | 2F5 |
| Isotype | HumanIgG2&lamBDa;. |
| Source/Host | HEK293cells |
| Immunogen/Antigen | RecombinanthumanNetrin-1. |
| Label/Conjugates | PreservativeFree |
| Application | ELISA Functional:InhibitstheactivationofhumanandmouseNetrin-1tohumanormousereceptorsDCCorUNC5(KDantibody-Netrin-1is1.5nM). |
| Crossreactivity | Human Mouse |
| Specificity | RecognizeshumanandmouseNetrin-1.DoesnotrecognizeNetrin-4.BlockshumanandmouseNetrin-1activityontumorcelllinesinvitroandinvivo.InhibitsNetrin-1-enhancedinfectivityofHepatitisCVirusparticles. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinA-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glycerol. |
| OtherProductData | anti-Netrin-1(human),mAb(rec.)(blocking)(2F5)iscomposedofhumanvariableregions(VHandVL)(λ-chain)ofimmunoglobulinfusedtothehumanlgG2Fcdomain. FornegativecontrolseeProd.No.AG-27B-0020PF. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Netrin-1controlsguidanceofCNScommissuralaxonsandperipheralmotoraxons.ItsassociationwitheitherDCCorsomeUNC5receptorswillleadtoaxonattractionorrepulsion,respectively.Italsoservesasasurvivalfactorviaitsassociationwithitsreceptorswhichpreventtheinitiationofapoptosis.Netrin-1isalsoinvolvedintumOrigenesisbyregulatingapoptosis.Netrin-1promotesatherosclerosisbyretainingmacrophagesinthearterywall.Netrin-1alsogovernsinducedpluripotentstemcell(iPS)formationandimprovesreprogrammingefficiencyofhumanandmousesomaticcellsbylimitingapoptosismediatedbyNetrin-1receptorsDCCorUNC5b.
ProductReferences
- Netrin-1regulatessomaticcellreprogrammingandpluripotencymaintenance:D.Ozmandenci,etal.;Nat.Commun. 6, 7398(2015)
- EpidermalGrowthFactorReceptor-DependentMutualAmplificationbetweenNetrin-1andtheHepatitisCVirus:M.L.Plissonnier,etal.;PLoSBiol.14,e1002421(2016)
- Targetingnetrin-1/DCCinteractionindiffuselargeB-cellandmantlecelllymphomas:T.Broutier,etal.;EMBOMol.Med.8,96(2016)
- Netrin-1actsasanon-canonicalangiogenicfactorproducedbyhumanWharton’sjellymesenchymalstemcells(WJ-MSC):C.P.Prieto,etal.;StemCellRes.Ther.8,43(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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