Adipogen/anti-mTOR, mAb (53E11)/YIF-LF-MA0365/100 µl
商品编号：
YIF-LF-MA0365
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | mTOR;MTOR;FRAP;EC=2.7.11.1;RapamycinTargetProtein1;MammalianTargetofRapamycin;RapamycinandFKBP12target1;MechaNISTicTargetofRapamycin;Serine/Threonine-ProteinKinasemTOR |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 53E11 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanHis-mTORproteinpurifiedfromE.coli. |
| Application | WesternBlot(1:2,000) |
| Crossreactivity | Human |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Mammaliantargetofrapamycin(mTOR),aserine/threoninekinaseinvolvedindiversecellularprocesses,includingproteintranslation,mRNAturnover,andproteinstability,mediates,atleastinpart,someoftheBIOLOGicalactionsofAkt.AsaKinasesubunitofbothmTORC1(complex1)andmTORC2(complex2),mTORregulatescellgrowthandsurvivalinresponsetonutrientandhormonalsignals.mTORC1isactivatedinresponsetogrowthfactorsoramino-acids.ActivatedmTORC1up-regulatesproteinsynthesisbyphosphorylatingkeyregulatorsofmRNAtranslationandribosomesynthesis.mTORC1phosphorylatesEIF4EBP1andreleasesitfrominhibitingtheelongationinitiationfactor4E(eiF4E).mTORC2seemstofunctionupstreamofRhoGTPasestoregulatetheactinCytoskeleton,probablybyactivatingoneormoreRho-typeguaninenucleotideexchangefactors.mTORC2promotestheserum-inducedformationofstress-fibersorF-actin.mTORC2playsacriticalroleinAKT1"Ser-473"phosphorylation.KinasesubunitofbothmTORC1andmTORC2,whichregulatescellgrowthandsurvivalinresponsetonutrientandhormonalsignals.mTORC1isactivatedinresponsetogrowthfactorsoramino-acids.Growthfactor-stimulatedmTORC1activationinvolvesAKT1-mediatedphosphorylationofTSC1-TSC2,whichleadstotheactivationoftheRHEBGTPasethatpotentlyactivatestheproteinkinaseactivityofmTORC1.Amino-acid-signalingtomTORC1requiresitsrelocalizationtothelysosomesmediatedbytheRagulatorcomplexandtheRagGTPases.ActivatedmTORC1up-regulatesproteinsynthesisbyphosphorylatingkeyregulatorsofmRNAtranslationandribosomesynthesis.mTORC1phosphorylatesEIF4EBP1andreleasesitfrominhibitingtheelongationinitiationfactor4E(eiF4E).mTORC1phosphorylatesandactivatesS6K1at"Thr-421",whichthenpromotesproteinsynthesisbyphosphorylatingPDCD4andtargetingitfordegradation.PhosphorylatesMAF1leADIngtoattenuationofitsRNApolymeraseIII-repressivefunction.mTORC2isalsoactivatedbygrowth.factors,butseemstobenutrient-insensitive.mTORC2seemstofunctionupstreamofRhoGTPasestoregulatetheactincytoskeleton,probablybyactivatingoneormoreRho-typeguaninenucleotideexchangefactors.mTORC2promotestheserum-inducedformationofstress-fibersorF-actin.mTORC2playsacriticalroleinAKT1"Ser-473"phosphorylation,whichmayfacilitatethephosphorylationoftheactivationloopofAKT1on"Thr-308"byPDK1whichisaprerequisiteforfullactivation.mTORC2regulatesthephosphorylationofSGK1at"Ser-422".mTORC2alsomodulatesthephosphorylationofPRKCAon"Ser-657".
ProductReferences
1)Sukumari-RameshS.Etal.(2011)Surg.Neurol.Int.23;2:22.(General)
2)DufnerA.,ThomasG.(1999)Exp.CellRes.253:100–109.(General)
3)GingrasA.C.Etal.(1998)GenesDev.12:502–13.(General)
4)MamaneY.Etal.(2006)Oncogene.25:6416–22.(General)
5)KimD.-H.Etal.(2002)Cell110:163-175.(General)
6)HaraK.Etal.(2002)Cell110:177-189.(General)
7)KimD.-H.Etal.(2003)Mol.Cell11:895-904.(General)
8)SarbassovD.D.Etal.(2004)Curr.Biol.14:1296-1302.(General)
9)JacintoE.Etal.(2004)Nat.CellBiol.6:1122-1128.(General)
10)SarbassovD.D.Etal.(2005)Science307:1098-1101.(General)
11)Garcia-MartinezJ.M.,AlessiD.R.(2008)Biochem.J.416:375-385.(General)
12)SancakY.Etal.(2008)Science320:1496-1501.(General)
2)DufnerA.,ThomasG.(1999)Exp.CellRes.253:100–109.(General)
3)GingrasA.C.Etal.(1998)GenesDev.12:502–13.(General)
4)MamaneY.Etal.(2006)Oncogene.25:6416–22.(General)
5)KimD.-H.Etal.(2002)Cell110:163-175.(General)
6)HaraK.Etal.(2002)Cell110:177-189.(General)
7)KimD.-H.Etal.(2003)Mol.Cell11:895-904.(General)
8)SarbassovD.D.Etal.(2004)Curr.Biol.14:1296-1302.(General)
9)JacintoE.Etal.(2004)Nat.CellBiol.6:1122-1128.(General)
10)SarbassovD.D.Etal.(2005)Science307:1098-1101.(General)
11)Garcia-MartinezJ.M.,AlessiD.R.(2008)Biochem.J.416:375-385.(General)
12)SancakY.Etal.(2008)Science320:1496-1501.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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