脂肪原/抗MKP1，单克隆抗体（PK4-1B8）/YIF-LF-MA0372/100µl
商品编号：
YIF-LF-MA0372
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CL100;DUSP1;MKP-1;EC=3.1.3.16;EC=3.1.3.48;MAPKinasePhosphatase1;Protein-TyrosinePhosphataseCL100;DualSpecificityProteinPhosphatase1;DualSpecificityProteinPhosphatasehVH1 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | PK4-1B8 |
| Isotype | MouseIgG2b |
| Immunogen/Antigen | RecombinanthumanproteinpurifiedfromE.coli. |
| Application | WesternBlot(1:5,000) Immunoprecipitation(2ul) |
| Crossreactivity | Human |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Dualspecificityproteinphosphatase1(alsoknownasHVH1;MKP1;CL100;MKP-1;PTPN10)isanenzymethatinhumansisencodedbytheDUSP1gene[1,2].TheexpressionofDUSP1geneisinducedinhumanskinfibroblastsbyoxidative/heatstressandgrowthfactors.Itspecifiesaproteinwithstructuralfeaturessimilartomembersofthenon-receptor-typeprotein-tyrosinephosphatasefamily,andwhichhassignificantamino-acidsequencesimilaritytoaTyr/Ser-proteinphosphataseencodedbythelategeneH1ofvacciniavirus.ThebacteriallyexpressedandpurifiedDUSP1proteinhasintrinsicphosphataseactivity,andspecificallyinactivatesmitogen-activatedprotein(MAP)kinaseinvitrobytheconcomitantdephosphorylationofbothitsphosphothreonineandphosphotyrosineresidues.FurThermore,itsuppressestheactivationofMAPkinasebyoncogenicrasinextractsofXenopusoocytes.Thus,DUSP1mayplayanimportantroleinthehumancellularresponsetoenvironmentalstressaswellasinthenegativeregulationofcellularproliferation[3].DUSP1hasbeenshowntointeractwithMAPK14[4][5],MAPK1[5][6]andMAPK8[5].DualspecificityphosphatasethatdephosphorylatesMAPkinaseMAPK1/ERK2onboth"Thr-183"and"Tyr-185",regulatingitsactivityduringthemeioticcellcycle.
ProductReferences
1)KeyseSMandEmslieEA(1992),"Oxidativestressandheatshockinduceahumangeneencodingaprotein-tyrosinephosphatase".Nature359(6396):644–7.(General)
2)MartellKJ,etal.(1995),"ChromosomallocalizationoffourhumanVH1-likeprotein-tyrosinephosphatases".Genomics22(2):462–4.(General)
3)"EntrezGene:DUSP1dualspecificityphosphatase1"(General)
4)Tanoue,T,etal.(2001),"ANovelMAPKphosphataseMKP-7actspreferentiallyonJNK/SAPKandp38alphaandbetaMAPKs".J.Biol.Chem.(UnitedStates)276(28):26629–39.(General)
5)Slack,DN,etal.(2001),"DistinctbindingdeterminantsforERK2/p38alphaandJNKmapkinasesmediatecatalyticactivationandsubstrateselectivityofmapkinasephosphatase-1".J.Biol.Chem.(UnitedStates)276(19):16491–500.(General)
6)Calvisi,DF,etal.(2008),"Dual-specificityphosphatase1ubiquitinationinextracellularsignal-regulatedkinase-mediatedcontrolofgrowthinhumanhepatocellularcarcinoma".CancerRes.(UnitedStates)68(11):4192–200.(General)
2)MartellKJ,etal.(1995),"ChromosomallocalizationoffourhumanVH1-likeprotein-tyrosinephosphatases".Genomics22(2):462–4.(General)
3)"EntrezGene:DUSP1dualspecificityphosphatase1"(General)
4)Tanoue,T,etal.(2001),"ANovelMAPKphosphataseMKP-7actspreferentiallyonJNK/SAPKandp38alphaandbetaMAPKs".J.Biol.Chem.(UnitedStates)276(28):26629–39.(General)
5)Slack,DN,etal.(2001),"DistinctbindingdeterminantsforERK2/p38alphaandJNKmapkinasesmediatecatalyticactivationandsubstrateselectivityofmapkinasephosphatase-1".J.Biol.Chem.(UnitedStates)276(19):16491–500.(General)
6)Calvisi,DF,etal.(2008),"Dual-specificityphosphatase1ubiquitinationinextracellularsignal-regulatedkinase-mediatedcontrolofgrowthinhumanhepatocellularcarcinoma".CancerRes.(UnitedStates)68(11):4192–200.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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