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Adipogen/anti-MEK6 (MAP Kinase Kinase 6), mAb (AF4G6)/YIF-LF-MA0291/100 µl
Adipogen/anti-MEK6 (MAP Kinase Kinase 6), mAb (AF4G6)/YIF-LF-MA0291/100 µl
商品编号：
YIF-LF-MA0291
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | MEK6;MEK6;MAP2K6;SAPKK3;MAPKK6;SAPKK-3;EC=2.7.12.2;SAPKKinase3;MAPK/ERKKinase6;MAPKinaseKinase6;Stress-activatedProteinKinaseKinase3 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | AF4G6 |
| Isotype | MouseIgG2aκ |
| Immunogen/Antigen | RecombinanthumanHis-MEK6proteinpurifiedfromE.coli. |
| Application | ELISA Immunoprecipitation(2μl) |
| Crossreactivity | Human |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
SequentialactivationofproteinkinaseswithintheMAPK(mitogen-activatedproteinkinases)cascadesisacommonmechanismofsignaltransductioninmanycellularprocesses.TheERKsignalingcascadeisacentralMAPKpathwaythatplaysaroleintheregulationofvariouscellularprocessessuchasproliferation,differentiation,development,learning,andsurvival.Mitogen-activatedproteinkinasekinases(MAPKK)phosphorylateMAPK.MEK(MAPkinaseorERKkinase)istheimmediateupstreamactivatorkinaseofERK.MEK6encodesa334-aminoacidproteinwith82%identitytoMKK3.MEK6ishighlyexpressedinskeletalmusclelikemanyothermembersofthisfamily,butincontrasttoMKK3itsexpressioninleukocytesisverylow.ThehumanMEKs(MEK1,MEK2,MEK3)showremarkablydifferentactivitytowardERKlandERK2.MEK2isthemostactiveERKactivator.MEK3isinactivetowardERKlorERK2.MEK3,MEK4,andMEK6phosphorylateandactivatep38MAPkinase.Thep38mitogen-activatedprotein(MAP)kinasesignaltransductionpathwayisactivatedbyproinflammatorycytokinesandenvironmentalstress.TranscriptionfactorssuchasATF2andElk-1aretargetsofthep38MAPkinasesignaltransductionpathway.CatalyzestheconcomitantphosphorylationofathreonineandatyrosineresidueinMAPkinasep38exclusively.
ProductReferences
1)ShaulYDandSegerR,(2007)BiochimBiophysActa1773(8):1213-1226.(General)
2)RaingeaudJetal.,(1996)MolCellBiol16(3):1247-1255.(General)
3)SteinBetal.,(1996)JBiolChem271(19):11427-11433.(General)
4)ZhengCFandGuanKL,(1993)JBiolChem268:11435-11439.(General)
2)RaingeaudJetal.,(1996)MolCellBiol16(3):1247-1255.(General)
3)SteinBetal.,(1996)JBiolChem271(19):11427-11433.(General)
4)ZhengCFandGuanKL,(1993)JBiolChem268:11435-11439.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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