Adipogen/anti-Lyn, pAb/YIF-LF-PA0074/100 µl
商品编号：
YIF-LF-PA0074
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | LYN;JTK8;p56Lyn;p53Lyn;EC=2.7.10.2;Tyrosine-ProteinKinaseLyn;Lck/Yes-relatedNovelProteinTyrosineKinase;V-yes-1YamaguchiSarcomaViralRelatedOncogeneHomolog |
| ProductType | PolyclonalAntibody |
| Properties | |
| Immunogen/Antigen | Syntheticpeptide. |
| Application | WesternBlot(1:2,000) |
| Crossreactivity | Human Mouse Rat |
| PurityDetail | Affinitypurification. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
ThemembersoftheSrc-familykinasesareSrc,Lyn,Fyn,Yes,Hck,Lck,Fgr,Blk,andYrk.EachofthesehaveacommonstructureconsistingofanuniquedomainattheN-terminal,followedbySH3,SH2andtyrosinekinasedomains.Inimmumecells,theSrc-familykinasesplayrolesascriticalregulatorsofalargenumberofintracellularsignalingpathways,includingintegrinsignalingpathway.Integrinsaremajorcellularreceptorthatmediatecelltocellandcelltosubstratuminteractions.TheintracellularproteinkinaseLynparticipatesbothpositivelyandnegativelyinBcell,mastcell,plateletandmyeloidcellsignaling.LynisthepredominantlyexpressedSrc-familykinaseinBcellsanditspositiveroleisdonethroughphosphorylationoftheIgαandIgβsubunitsofBcellreceptor.GeneticdeletionofLynresultsinautoimmunity,renaldiseaseandprematuremortalityinmice,andgenerationofhyperactiveLynresultsinthesamephenotype,revealingtheimportanceofthebalanceofLynsignaling.Downregulatesexpressionofstemcellgrowthfactorreceptor(KIT).ActsasaneffectorofEpoR(erythropoietinreceptor)incontrollingKITexpressionandmayplayacentralroleinerythroiddifferentiationduringtheswitchbetweenproliferationandmaturationBysimilarity.ActsasapositiveregulatorofcellmovementwhilenegativelyregulatingadhesiontostromalcellsbyinhibitingtheICAM-1-bindingactivityofβ-2integrins.ActsasthemediatorthatrelayssuppressingsignalsfromthechemokinereceptorCXCR4toβ-2integrinLFA-1inhematopoieticprecursors.Involvedininductionofstress-activatedproteinkinase(SAPK),butnotERKorp38MAPK,inresponsetogenotoxicagents.InducesSAPKbyaMKK7-andMEKK1-dependentmechanism.TheLYN->MEKK1->MKK7->SAPKpathwayisfunctionalintheinductionofapoptosisbygenotoxicagents.
ProductReferences
1)XuY.etal.,(2005)Immunity.22:9-18.(General)
2)LowellC.A.,2004.MolImmunol.41:631-643.(General)
3)PereiraS.andLowellC.,(2003)JImmunol.171:1319-1327.(General)
2)LowellC.A.,2004.MolImmunol.41:631-643.(General)
3)PereiraS.andLowellC.,(2003)JImmunol.171:1319-1327.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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