脂肪原/抗LT和β；R（小鼠），单克隆抗体（4H8 WH2）/AG-20B-0008-C100/100µg
商品编号：
AG-20B-0008-C100
品牌：
Adipogen Inc
市场价：
¥4400.00
美元价：
2640.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Lymphotoxin-βReceptor;TumorNecrosisFactorReceptor2RelatedProtein;TumorNecrosisFactorCReceptor;TumorNecrosisFactorReceptorSuperfamilyMember3;TNFRSF3 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 4H8WH2 |
| Isotype | RatIgG2a |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | RecombinantmouseLTβR(cysteine-richregion/aa31-221). |
| Application | FlowCytometry FunctionalApplication:AgoNISTinducingBAFF,chemokinesandintegrinsinvitroandinvivo. |
| Crossreactivity | Mouse |
| Specificity | RecognizesmouseLTβR. |
| Purity | ≥95%(SDS-PAGE) |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| OtherProductData | ThemonoclonalantibodytomouseLTβRisanagonistthatcanbeusedfortheinvestigationoftheregulationofBAFF(BlyS),chemokinesandintegrinsusinginvivoandtissueculturemodels,thedevelopmentofNKcellsandNKTcells,tostudytheregulationofNF-κBfamilyoftranscriptionfactorsinregulationofinflammationandhomeostasis,particularlyRelBNF-κB2pathway.ForuseasanagonisttheMAbtoLTβRisaddedtocellculturesat2μg/ml.Forinvivouse,miceareinjectedintraperitoneallywith50μgofagonisticMAbtoLTβRinsterilephosphatesalinebuffer. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
TheLTβRactivatestwodifferentNF-κBpathwaysthatleadtodistinctpatternsofgeneinduction,includingselectedchemokinesandthecytokineBAFF,whichisessentialforthesurvivalofmatureBlymphocytes.LTβRactivatestheclassicalNF-κB(relA/p50)pathway,likethetype1TNFreceptor(TNFR1),thatregulatesproinflammatorygenes,likethechemokineMIP1β.However,LTβR,unlikeTNFR1,alsoactivatestheprocessingofp100toformRelB/p52complexes,whichactivategenesinvolvedinlymphoidorganformationandlymphocytesurvival.
ProductReferences
- Thelymphotoxin-betareceptorinducesdifferentpatternsofgeneexpressionviatwoNF-kappaBpathways:E.Dejardin,etal.;Immunity17,525(2002)
- Lymphotoxin-mediatedregulationofgammadeltacelldifferentiationbyalphabetaTcellProgenitors:B.Silva-Santos,etal.;Science307,925(2005)
- LTβRSignalingInducesCytokineExpressionandUp-RegulatesLymphangiogenicFactorsinLymphNodeAnlagen.M.F.Vondenhoff,etal.;J.Immunol. 182,5439(2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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